1H-Imidazole, 1,1'-(1,2-dioxo-1,2-ethanediyl)bis[4-methyl- | 685880-49-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1H-Imidazole, 1,1'-(1,2-dioxo-1,2-ethanediyl)bis[4-methyl-
• 英文别名: 1,2-bis(4-methylimidazol-1-yl)ethane-1,2-dione
• CAS: 685880-49-3
• 化学式: C₁₀H₁₀N₄O₂
• 分子量: 218.21
• InChiKey: YHJYGNIYPOURDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  69.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Chemiluminescent Enzyme Assay Method and Apparatus
  申请人：Lee Ji Hoon

  公开号：US20110045506A1

  公开（公告）日：2011-02-24

  A chemiluminescent enzyme immunoassay method for quantifying antigen or antibody using 1,1′-oxalyldiimidazole (ODI) derivative or 1,1′-oxalyldisodium benzoate (ODB) derivative chemiluminescence (CL) detection was developed. Also, various enzymes were quantified using ODI derivative or DOB derivative CL detection. Fluorescent compound formed from a substrate (non-fluorescent compound) through the enzyme assay methods emitted CL when the fluorescent compound received energy from high-energy intermediate formed in ODI derivative or ODB derivative CL reaction.
• Method For Enhancing Enzyme Assays
  申请人：LEE Ji Hoon

  公开号：US20120237957A1

  公开（公告）日：2012-09-20

  Additives capable of controlling the reaction rate between substrate and enzyme to form a dye in enzyme assays with absorbance, chemiluminescence, and fluorescence are effective tools for optimizing enzyme assays. A dye can be formed rapidly from the reaction between enzyme and substrate in the presence of a catalyst. Using relatively high concentration of dye formed from the rapid reaction, trace levels of analytical materials can be quantified using absorbance, chemiluminecence and fluorescence detection. A dye can be formed from a relatively slow reaction between enzyme and substrate in the presence of a surfactant such as Triton X-100 and β-cyclodextrin. Using relatively low concentration of dye from the slow reaction, a high concentration of analytical material can be quantified without any dilution using absorbance, chemiluminescence, and fluorescence.
• CHEMILUMINESCENT ENZYME ASSAY METHOD AND APPARATUS
  申请人：Lee, SR. Ji Hoon

  公开号：US20130288270A1

  公开（公告）日：2013-10-31

  A chemiluminescent enzyme immunoassay method for quantifying antigen or antibody using 1,1′-oxalyldiimidazole (ODI) derivative or 1,1′-oxalyldisodium benzoate (ODB) derivative chemiluminescence (CL) detection was developed. Also, various enzymes were quantified using ODI derivative or DOB derivative CL detection. Fluorescent compound formed from a substrate (non-fluorescent compound) through the enzyme assay methods emitted CL when the fluorescent compound received energy from high-energy intermediate formed in ODI derivative or ODB derivative CL reaction.
• CHEMILUMINESCENT APTASENSORS
  申请人：LUMINESCENT MD, LLC

  公开号：US20150276725A1

  公开（公告）日：2015-10-01

  A chemiluminescent immunoassay for sensing an analyte in a sample includes an oligonucleotide, a buffer solution, a chemiluminescent reagent, and a micro-particle or a nano-particle. An analyte in a sample is detected by conjugating an oligonucleotide with (i) a fluorescent dye or a fluorescent polystyrene bead and (ii) a micro-particle or a nano-particle; mixing the conjugated oligonucleotide and a chemiluminescent reagent; and measuring light intensity generated as a result of mixing the conjugated oligonucleotide and chemiluminescent reagent. The oligonucleotide advantageously captures and detects the analyte without the requirement of an anti-body. The micro-particle or nano-particle removes excess oligonucleotide without the requirement of washing.
• METHOD FOR ENHANCING ENZYME ASSAYS
  申请人：LUMINESCENT MD, LLC

  公开号：US20150301036A1

  公开（公告）日：2015-10-22

  Additives capable of controlling the reaction rate between substrate and enzyme to form a dye in enzyme assays with absorbance, chemiluminescence, and fluorescence are effective tools for optimizing enzyme assays. A dye can be formed rapidly from the reaction between enzyme and substrate in the presence of a catalyst. Using relatively high concentration of dye formed from the rapid reaction, trace levels of analytical materials can be quantified using absorbance, chemiluminecence and fluorescence detection. A dye can be formed from a relatively slow reaction between enzyme and substrate in the presence of a surfactant such as Triton® X-100 and β-cyclodextrin. Using relatively low concentration of dye from the slow reaction, a high concentration of analytical material can be quantified without any dilution using absorbance, chemiluminescence, and fluorescence.