5-methyl-6-phenyl-imidazo[2,1-b][1,3,4]thiadiazole-2-sulfonic acid amide | 63735-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-methyl-6-phenyl-imidazo[2,1-b][1,3,4]thiadiazole-2-sulfonic acid amide
• 英文别名: 5-Methyl-6-phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide；5-methyl-6-phenylimidazo[2,1-b][1,3,4]thiadiazole-2-sulfonamide
• CAS: 63735-72-8
• 化学式: C₁₁H₁₀N₄O₂S₂
• 分子量: 294.358
• InChiKey: AXKFSFPCHIIEKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  127
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Imidazo [2,1-b]-1,3,4-thiadiazole suflonamides
  申请人：Jaquith B. James

  公开号：US20050069492A1

  公开（公告）日：2005-03-31

  This invention relates to compounds of Formula (I) and the use of compounds of Formula (I) as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems.

  本发明涉及公式（I）的化合物以及在治疗中枢和周围神经系统的神经元疾病中使用公式（I）化合物作为神经保护剂的用途。
• Imidazo[2,1-b]-1,3,4-thiadiazole sulfonamides
  申请人：Jaquith B. James

  公开号：US20070088059A1

  公开（公告）日：2007-04-19

  This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems. Formula I:

  本发明涉及I式化合物及其在治疗中枢和周围神经系统神经元疾病中作为神经保护剂的应用。I式：
• IMIDAZO [2,1,-b]-1,3,4-THIADIAZOLE SULFONAMIDES
  申请人：JAQUITH James B.

  公开号：US20090042953A1

  公开（公告）日：2009-02-12

  This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems. Formula I:

  本发明涉及公式I化合物及其作为神经保护剂用于治疗中枢和外周神经系统的神经元疾病的用途。公式I：
• IMIDAZO¬2,1-B -1,3,4-THIADIAZOLE SULFONAMIDES
  申请人：Aegera Therapeutics Inc.

  公开号：EP1463735B1

  公开（公告）日：2009-08-12
• USE OF IMIDAZO[2,1-b]-1,3,4-THIADIAZOLE-2-SULFONAMIDE COMPOUNDS TO TREAT NEUROPATHIC PAIN
  申请人：Durkin Jon

  公开号：US20090170845A1

  公开（公告）日：2009-07-02

  Disclosed herein are methods and compositions for treating and/or prophylaxis of neuropathic pain in a subject. The methods comprise administering to the subject suffering from neuropathic pain, a therapeutically effective amount of a compound, according to Formula I: or a salt thereof, wherein A, R 5 and R 6 are defined herein.