1,8-Dihydroxy-3-[(4-hydroxyphenyl)methyl]anthracene-9,10-dione | 155920-54-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1,8-Dihydroxy-3-[(4-hydroxyphenyl)methyl]anthracene-9,10-dione
• CAS: 155920-54-0
• 化学式: C₂₁H₁₄O₅
• 分子量: 346.339
• InChiKey: PBEFTHGCMLAKAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,8-Dihydroxy-3-[(4-hydroxyphenyl)methyl]anthracene-9,10-dione 在 盐酸 、 溶剂黄146 、 tin(ll) chloride 作用下， 以46%的产率得到1,8-Dihydroxy-3-(4-hydroxy-benzyl)-10H-anthracen-9-one
  参考文献：
  名称：

  Antipsoriatic Anthrones with Modulated Redox Properties. 2. Novel Derivatives of Chrysarobin and Isochrysarobin-Antiproliferative Activity and 5-Lipoxygenase Inhibition

  摘要：

  A novel series of 2- and 3-substituted 1,8-dihydroxy-9(10H)-anthracenones were synthesized and tested for their inhibitory activity against 5-lipoxygenase (5-LO) in bovine polymorphonuclear leukocytes and the growth of human keratinocytes. Structure-activity relationships are discussed with respect to the following redox properties of the compounds: reactivity against 2,2-diphenyl-1-picrylhydrazyl, generation of hydroxyl radicals as measured by deoxyribose degradation, and inhibition of lipid peroxidation in model membranes. Inhibition of cell proliferation seemed to be related to these properties, whereas 5-LO inhibition was not. Within a class of structural analogs the activity against 5-LO, which was markedly improved as compared to that of the antipsoriatic drug anthralin, correlated well with the overall lipophilicity. Even though a number of compounds in this series enhanced oxidative damage to nonlipid molecules such as deoxyribose, their antioxidant properties predominate in membrane lipids. Among the prooxidant compounds were also the most potent antiproliferative agents (IC50 values in the 10(-7) M range).

  DOI：

  10.1021/jm00037a017
• 作为产物：
  描述：

  3-(氯甲基)-1,8-二羟基蒽-9,10-二酮 在 三氯化铝 、 氢溴酸 、 溶剂黄146 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 4.0h， 生成 1,8-Dihydroxy-3-[(4-hydroxyphenyl)methyl]anthracene-9,10-dione
  参考文献：
  名称：

  Antipsoriatic Anthrones with Modulated Redox Properties. 2. Novel Derivatives of Chrysarobin and Isochrysarobin-Antiproliferative Activity and 5-Lipoxygenase Inhibition

  摘要：

  A novel series of 2- and 3-substituted 1,8-dihydroxy-9(10H)-anthracenones were synthesized and tested for their inhibitory activity against 5-lipoxygenase (5-LO) in bovine polymorphonuclear leukocytes and the growth of human keratinocytes. Structure-activity relationships are discussed with respect to the following redox properties of the compounds: reactivity against 2,2-diphenyl-1-picrylhydrazyl, generation of hydroxyl radicals as measured by deoxyribose degradation, and inhibition of lipid peroxidation in model membranes. Inhibition of cell proliferation seemed to be related to these properties, whereas 5-LO inhibition was not. Within a class of structural analogs the activity against 5-LO, which was markedly improved as compared to that of the antipsoriatic drug anthralin, correlated well with the overall lipophilicity. Even though a number of compounds in this series enhanced oxidative damage to nonlipid molecules such as deoxyribose, their antioxidant properties predominate in membrane lipids. Among the prooxidant compounds were also the most potent antiproliferative agents (IC50 values in the 10(-7) M range).

  DOI：

  10.1021/jm00037a017