1-<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-indol-3-yl>pentanoyl>piperidin-4-one | 158387-39-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-indol-3-yl>pentanoyl>piperidin-4-one
• 英文别名: 1-[6-(5-Chloro-1-methyl-2-pyridin-3-ylindol-3-yl)hexanoyl]piperidin-4-one
• CAS: 158387-39-4
• 化学式: C₂₅H₂₈ClN₃O₂
• 分子量: 437.969
• InChiKey: MSOSYHZLKWROFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  55.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-indol-3-yl>pentanoyl>piperidin-4-one 在 sodium cyanoborohydride 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 反应 1.0h， 生成 2-<<1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-6-<<1-<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-indol-3-yl>pentanoyl>piperidin-4-yl>amino>hexanoic acid
  参考文献：
  名称：

  Dual Angiotensin Converting Enzyme/Thromboxane Synthase Inhibitors

  摘要：

  A variety of compounds were prepared to determine whether dual angiotensin converting enzyme (ACE)/thromboxane synthase (TxS) inhibition could be obtained in the same molecule. These compounds would be used to explore the concept that a dual inhibitor would have superior antihypertensive activity in the spontaneous hypertensive rat compared to an ACE inhibitor. Potent in vitro dual ACE and TxS inhibition was obtained in the same molecule with five series of compounds. Potent blood pressure lowering in the SHR was observed after oral administration of 8b and 11. However, a correlation between blood pressure lowering and the Al presser response inhibition was not observed. The blood pressure-lowering actions of enalapril were significantly potentiated by concurrent administration of 3, a thromboxane synthase inhibitor. Analysis of the area under the curve for 24 h showed nearly a doubling of the blood pressure-lowering effect.

  DOI：

  10.1021/jm00038a011
• 作为产物：
  描述：

  4-氧代哌啶酮盐酸盐 、 3-(5-carboxypentyl)-5-chloro-1-methyl-2-(pyridin-3-yl)indole 在 TEA 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以1.81 g的产率得到1-<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-indol-3-yl>pentanoyl>piperidin-4-one
  参考文献：
  名称：

  Dual Angiotensin Converting Enzyme/Thromboxane Synthase Inhibitors

  摘要：

  A variety of compounds were prepared to determine whether dual angiotensin converting enzyme (ACE)/thromboxane synthase (TxS) inhibition could be obtained in the same molecule. These compounds would be used to explore the concept that a dual inhibitor would have superior antihypertensive activity in the spontaneous hypertensive rat compared to an ACE inhibitor. Potent in vitro dual ACE and TxS inhibition was obtained in the same molecule with five series of compounds. Potent blood pressure lowering in the SHR was observed after oral administration of 8b and 11. However, a correlation between blood pressure lowering and the Al presser response inhibition was not observed. The blood pressure-lowering actions of enalapril were significantly potentiated by concurrent administration of 3, a thromboxane synthase inhibitor. Analysis of the area under the curve for 24 h showed nearly a doubling of the blood pressure-lowering effect.

  DOI：

  10.1021/jm00038a011

文献信息

• Dual Angiotensin Converting Enzyme/Thromboxane Synthase Inhibitors
  作者：Gary M. Ksander、Mark Erion、Andrew M. Yuan、Clive G. Diefenbacher、Lena El-Chehabi、Don Cote、Nigel Levens

  DOI：10.1021/jm00038a011

  日期：1994.6

  A variety of compounds were prepared to determine whether dual angiotensin converting enzyme (ACE)/thromboxane synthase (TxS) inhibition could be obtained in the same molecule. These compounds would be used to explore the concept that a dual inhibitor would have superior antihypertensive activity in the spontaneous hypertensive rat compared to an ACE inhibitor. Potent in vitro dual ACE and TxS inhibition was obtained in the same molecule with five series of compounds. Potent blood pressure lowering in the SHR was observed after oral administration of 8b and 11. However, a correlation between blood pressure lowering and the Al presser response inhibition was not observed. The blood pressure-lowering actions of enalapril were significantly potentiated by concurrent administration of 3, a thromboxane synthase inhibitor. Analysis of the area under the curve for 24 h showed nearly a doubling of the blood pressure-lowering effect.