2-cyclohexylmethyl-1,2,3,4,6,7,12,12b-octahydropyrazino<1',2':1,2>pyrido<3,4-b>indole | 137606-60-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-cyclohexylmethyl-1,2,3,4,6,7,12,12b-octahydropyrazino<1',2':1,2>pyrido<3,4-b>indole
• 英文别名: 4-(Cyclohexylmethyl)-4,7,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),11,13,15-tetraene
• CAS: 137606-60-1
• 化学式: C₂₁H₂₉N₃
• 分子量: 323.481
• InChiKey: ZJLBHFYUKYRXGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  22.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(cyclohexylcarbonyl)-1,2,3,4,6,7,12,12b-octahydropyrazino[2,1-a]β-carbolin-4-one 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以76%的产率得到2-cyclohexylmethyl-1,2,3,4,6,7,12,12b-octahydropyrazino<1',2':1,2>pyrido<3,4-b>indole
  参考文献：
  名称：

  Synthesis and hypotensive activities of octahydropyrazino[1′,2′:1,2]pyrido[3,4-b]indoles and 15-azayohimbanes

  摘要：

  The hypotensive activities in rats of indolic compounds 1-9 were compared with that of reserpine. In spite of differences in their structure, all 9 showed similar hypotensive activities to that of reserpine. New octahydropyrazinopyridoindoles 3-6 and the tetrahydro-beta-carboline 7 were synthesized.

  DOI：

  10.1016/0223-5234(94)90114-7

文献信息

• Synthesis and hypotensive activities of octahydropyrazino[1′,2′:1,2]pyrido[3,4-b]indoles and 15-azayohimbanes
  作者：N VALLS、V SEGARRA、A TOST、G ROSELL

  DOI：10.1016/0223-5234(94)90114-7

  日期：——

  The hypotensive activities in rats of indolic compounds 1-9 were compared with that of reserpine. In spite of differences in their structure, all 9 showed similar hypotensive activities to that of reserpine. New octahydropyrazinopyridoindoles 3-6 and the tetrahydro-beta-carboline 7 were synthesized.