3-(2-methoxy-phenylamino)-butan-2-ol | 1220968-68-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(2-methoxy-phenylamino)-butan-2-ol
• 英文别名: 3-(2-Methoxyanilino)butan-2-ol；3-(2-methoxyanilino)butan-2-ol
• CAS: 1220968-68-2
• 化学式: C₁₁H₁₇NO₂
• 分子量: 195.261
• InChiKey: HPBNNPABPOHKBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙醇 、 邻甲氧基苯胺 在 叔丁基过氧化氢 、 titanium(III) chloride 作用下， 以 水 为溶剂， 以45%的产率得到3-(2-methoxy-phenylamino)-butan-2-ol
  参考文献：
  名称：

  Efficient radical domino approach to β-aminoalcohols from arylamines and alcohols triggered by Ti(III)/t-BuOOH

  摘要：

  We report that an aqueous Ti(III)/t-BuOOH system promotes the efficient domino radical reaction of arylamines with alcohol cosolvents leading to beta-aminoalcohols in good yields, in less than ten minutes at room temperature. The free-radical mechanism according to which the amine reacts with two molecules of the alcohol is discussed. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.01.039

文献信息

• Efficient radical domino approach to β-aminoalcohols from arylamines and alcohols triggered by Ti(III)/t-BuOOH
  作者：Raffaele Spaccini、Alessandra Ghilardi、Nadia Pastori、Angelo Clerici、Carlo Punta、Ombretta Porta

  DOI：10.1016/j.tet.2010.01.039

  日期：2010.3

  We report that an aqueous Ti(III)/t-BuOOH system promotes the efficient domino radical reaction of arylamines with alcohol cosolvents leading to beta-aminoalcohols in good yields, in less than ten minutes at room temperature. The free-radical mechanism according to which the amine reacts with two molecules of the alcohol is discussed. (C) 2010 Elsevier Ltd. All rights reserved.