2-methyl-2H-pyrazolo[3,4-b]pyridin-5-amine | 1363383-41-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 2-methyl-2H-pyrazolo[3,4-b]pyridin-5-amine
• 英文别名: 5-Amino-2-methyl-2H-pyrazolo[3,4-B]pyridine；2-methylpyrazolo[3,4-b]pyridin-5-amine
• CAS: 1363383-41-8
• 化学式: C₇H₈N₄
• 分子量: 148.167
• InChiKey: VMXGQYXXAIDTMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  56.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3-((tert-butoxycarbonyl)(methyl)amino)pyrrolidin-1-yl)-4-ethoxypyrimidine-5-carboxylic acid 、 2-methyl-2H-pyrazolo[3,4-b]pyridin-5-amine 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以73.53%的产率得到tert-butyl (1-(4-ethoxy-5-((2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)carbamoyl)pyrimidin-2-yl)pyrrolidin-3-yl)(methyl)carbamate
  参考文献：
  名称：

  [EN] 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME
  [FR] DÉRIVÉS D'ACÉTAMIDO-PHÉNYLTÉTRAZOLE ET LEURS MÉTHODES D'UTILISATION

  摘要：

  The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds of the present disclosure may act as small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded genes, and methods of use of the compounds for modulating splicing and treating related diseases and conditions. The compounds disclosed herein may possess activity toward various genetic pathways and are accordingly useful in methods of treatment of the human or animal body.

  公开号：

  WO2023102231A1

文献信息

• [EN] 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME<br/>[FR] DÉRIVÉS D'ACÉTAMIDO-PHÉNYLTÉTRAZOLE ET LEURS MÉTHODES D'UTILISATION
  申请人：[en]RGENTA THERAPEUTICS, INC.

  公开号：WO2023102231A1

  公开（公告）日：2023-06-08

  The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds of the present disclosure may act as small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded genes, and methods of use of the compounds for modulating splicing and treating related diseases and conditions. The compounds disclosed herein may possess activity toward various genetic pathways and are accordingly useful in methods of treatment of the human or animal body.