phenyl N-[4-[[tert-butyl(dimethyl)silyl]oxymethyl]-3-methoxyphenyl]carbamate | 1425051-86-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenyl N-[4-[[tert-butyl(dimethyl)silyl]oxymethyl]-3-methoxyphenyl]carbamate
• CAS: 1425051-86-0
• 化学式: C₂₁H₂₉NO₄Si
• 分子量: 387.551
• InChiKey: OWMQMCVECZNHNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.83
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  phenyl N-[4-[[tert-butyl(dimethyl)silyl]oxymethyl]-3-methoxyphenyl]carbamate 在 dibutyltin(II) dilaurate 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 水 、 甲苯 为溶剂， 反应 12.0h， 生成 [2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl N-[3-methoxy-4-[[3-methoxy-4-[(4-nitrophenyl)carbamoyloxymethyl]phenyl]carbamoyloxymethyl]phenyl]carbamate
  参考文献：
  名称：

  Effects of Electronics, Aromaticity, and Solvent Polarity on the Rate of Azaquinone–Methide-Mediated Depolymerization of Aromatic Carbamate Oligomers

  摘要：

  This paper uses physical-organic studies on well-defined oligomers to establish design principles for creating aromatic poly(carbamates) that depolymerize from head-to-tail in low dielectric constant environments when exposed to specific applied signals. We show that either increasing electron density or decreasing the aromaticity of aromatic repeating units in poly(carbamates) increase the overall depolymerization rate. For example, a methoxybenzene-based repeating unit provides depolymerization rates that are 143X faster than oligomers that contain a benzene-based repeating unit. Furthermore, the rate of depolymerization in the methoxybenzene-based system is tolerant to low dielectric environments, whereas the benzene-based oligomers are not.

  DOI：

  10.1021/jo400105m
• 作为产物：
  描述：

  2-甲氧基-4-硝基苯甲醛 在 咪唑 、 4-二甲氨基吡啶 、 sodium tetrahydroborate 、 palladium 10% on activated carbon 、 氢气 、 碳酸氢钠 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 3.0h， 生成 phenyl N-[4-[[tert-butyl(dimethyl)silyl]oxymethyl]-3-methoxyphenyl]carbamate
  参考文献：
  名称：

  Effects of Electronics, Aromaticity, and Solvent Polarity on the Rate of Azaquinone–Methide-Mediated Depolymerization of Aromatic Carbamate Oligomers

  摘要：

  This paper uses physical-organic studies on well-defined oligomers to establish design principles for creating aromatic poly(carbamates) that depolymerize from head-to-tail in low dielectric constant environments when exposed to specific applied signals. We show that either increasing electron density or decreasing the aromaticity of aromatic repeating units in poly(carbamates) increase the overall depolymerization rate. For example, a methoxybenzene-based repeating unit provides depolymerization rates that are 143X faster than oligomers that contain a benzene-based repeating unit. Furthermore, the rate of depolymerization in the methoxybenzene-based system is tolerant to low dielectric environments, whereas the benzene-based oligomers are not.

  DOI：

  10.1021/jo400105m

文献信息

• Qualitative and quantitative point-of-care assays
  申请人：The Penn State Research Foundation

  公开号：US09932360B2

  公开（公告）日：2018-04-03

  Disclosed herein are “equipment-free” flow-through assay devices based on patterned porous media, methods of making same, and methods of using same. The porous, hydrophilic media are patterned with hydrophobic barriers for performing assays on liquids.

  本文披露了基于图案化多孔介质的“无设备”流通测定装置，其制作方法和使用方法。这些多孔的亲水介质被图案化为带有疏水屏障，用于对液体进行测定。
• Phase-Switching Depolymerizable Poly(carbamate) Oligomers for Signal Amplification in Quantitative Time-Based Assays
  作者：Gregory G. Lewis、Jessica S. Robbins、Scott T. Phillips

  DOI：10.1021/ma4007413

  日期：2013.7.9

  This article describes the use of poly(carbamate) oligomers that depolymerize from head-to-tail as phase-switching reagents for increasing the sensitivity of quantitative point-of-care assays that are based on measurements of time. The poly(carbamate) oligomers selectively react with hydrogen peroxide (a model analyte) and provide sensitivity by depolymerizing in the presence of the analyte to convert from water-insoluble oligomers to water-soluble products. This switching reaction enables a sample to wick through a three-dimensional paper-based microfluidic device, where the flow-through time reflects the quantity of the analyte in the sample. Oligomers as short as octamers enable quantitative detection to low nanomolar concentrations of the analyte.