3-丁基吡嗪 | 28200-55-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 3-丁基吡嗪
• 中文别名: 3-丁基哒嗪
• 英文名称: 3-butyl-pyridazine
• 英文别名: 3-Butyl-pyridazin；butylpyridazine；3-Butylpyridazine
• CAS: 28200-55-7
• 化学式: C₈H₁₂N₂
• 分子量: 136.197
• InChiKey: XHQORXRKXJXPBL-UHFFFAOYSA-N

物化性质

• 沸点：
  77-82 °C(Press: 1 Torr)
• 密度：
  0.961±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  2-正丁基呋喃 在 1,4-二氧六环 、 溴 、 sodium carbonate 、 溶剂黄146 作用下， 反应 2.0h， 生成 3-丁基吡嗪
  参考文献：
  名称：

  Levisalles, Bulletin de la Societe Chimique de France, 1957, p. 1009,1011

  摘要：

  DOI：

文献信息

• COVALENTLY ATTACHED ANTIMICROBIAL POLYMERS
  申请人：Steinberg Thorsten

  公开号：US20130338326A1

  公开（公告）日：2013-12-19

  The present invention relates to substrates comprising covalently attached antimicrobial polymers, which act as synthetic mimics of antimicrobial peptides (SMAMPs) and are preferably obtained by ring opening metathesis polymerization (ROMP). The inventive antimicrobial polymers exhibit a molecular weight of more than 100,000 g mol −1 and are preferably covalently attached to the surface of a substrate, e.g. an implant, a medical device, medical equipment or a (tissue-supporting) biomaterial, etc. Covalent bonding may be carried out using a photoreactive crosslinker but also by “grafting onto” or “grafting from”. The present invention is also directed to uses of the inventive antimicrobial polymers as defined herein, e.g. for antimicrobially coating a surface of such a substrate with a layer of the inventive antimicrobial polymer.

  本发明涉及包含共价连接的抗菌聚合物的基板，这些聚合物作为抗菌肽（SMAMPs）的合成模拟体，并且最好是通过环烯烃开环甲基交换聚合（ROMP）获得的。这种创新的抗菌聚合物的分子量超过100,000克/摩尔，并且最好是共价连接到基板表面上，例如植入物、医疗器械、医疗设备或（支持组织的）生物材料等。共价键合可以使用光反应性交联剂进行，也可以通过“接枝到”或“接枝自”来进行。本发明还涉及如上所定义的创新抗菌聚合物的用途，例如，用创新抗菌聚合物的层对这种基板的表面进行抗菌涂层。
• [EN] 3,4-DIAMINOBENZENESULFONAMIDE DERIVATIVES FOR INHIBITING CELL DEATH<br/>[FR] DÉRIVÉS DE 3,4-DIAMINOBENZÈNESULFONAMIDE POUR INHIBER LA MORT CELLULAIRE
  申请人：VIB VZW

  公开号：WO2016075330A1

  公开（公告）日：2016-05-19

  The present invention relates to a novel class of compounds having the structure of formula (I) and pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof. These compounds inhibit or reduce the non-apoptotic cell death forms ferroptosis and/or oxytosis rendering them useful for the treatment of various conditions disclosed herein.

  本发明涉及一种新型化合物类，其结构式为(I)，以及包含式(I)化合物或其药学上可接受的盐的制药组合物。这些化合物抑制或减少非凋亡细胞死亡形式的铁死亡和/或氧死亡，因此可用于治疗本文所披露的各种疾病。
• Pharmaceutical composition for treatment of cancer containing pyridylpyridazine or transition metal complex thereof as active ingredient
  申请人：Sung Nack-Do

  公开号：US20090036418A1

  公开（公告）日：2009-02-05

  The present invention relates to a pharmaceutical composition for the treatment of cancer, which contains, as an active ingredient, a pyridylpyridazine compound or a transition metal complex thereof. As described above, the pyridylpyridazine compounds according to the present invention and the transition metal complexes thereof have anticancer activity and can be easily prepared at low cost. Thus, these compounds are useful as anticancer agents against various cancers, including lung cancer, adenocarcinoma, skin cancer, colon cancer, uterine cancer and brain cancer, which are expressed due to immune system abnormality.

  本发明涉及一种用于治疗癌症的药物组合物，其包含作为活性成分的吡啶基吡嗪化合物或其过渡金属配合物。如上所述，根据本发明，吡啶基吡嗪化合物及其过渡金属配合物具有抗癌活性，并且可以以低成本轻松制备。因此，这些化合物对包括肺癌、腺癌、皮肤癌、结肠癌、子宫癌和脑癌在内的各种癌症具有抗癌作用，这些癌症是由于免疫系统异常表达的。
• Use of a catalyst in epoxy compositions
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0328020A2

  公开（公告）日：1989-08-16

  Storage stable compositions are disclosed which comprise an epoxide containing compound, a phenolic hydroxyl containing compound, and a catalyst compound for catalyzing the reaction between epoxide groups and aromatic hydroxyl groups which catalyst comprises the product resulting from contacting an onium compound, non-heterocyclic amine compound, heterocyclic nitrogen compound or salt thereof with an acid or a salt of an acid having a weak nucleophilic anion.

  本发明公开了一种贮存稳定的组合物，该组合物包括一种含环氧化物的化合物、一种含酚羟基的化合物和一种催化环氧化物基团与芳香羟基基团反应的催化剂化合物，该催化剂包括鎓化合物、非杂环胺化合物、杂环氮化合物或其盐与酸或具有弱亲核阴离子的酸的盐接触后产生的产物。
• Latent catalysts, cure-inhibited epoxy resin compositions and laminates prepared therefrom
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0458502A2

  公开（公告）日：1991-11-27

  In summary, the application is related to the discovery of a class of compounds which comprises boric acid or maleic acid or a mixture of boric acid with at least one acid having a weak nucleophilic anion, which inhibits the reaction of a polyepoxide with a curing agent at low temperatures. In another embodiment the application is a latent catalyst system adapted for curing a polyepoxide resulting from contacting I) a catalyst for the cure of a polyepoxide compound comprising an amine, heterocyclic nitrogen phosphine, sulfide, phosphine, sulfide, ammonium, phosphonium, sulfonium, arsonium, containing compound or a mixture thereof; with II) boric acid, or a mixture of boric acid with at least an acid having a weak nucleophilic anion. Further the application relates to epoxy resin compositions containing the inhibitor or latent catalytic composition. In still another embodiment the application relates to a composition useful for curing a polyepoxide which contains: A) an inhibiting amount of boric acid or maleic acid or a mixture of boric acid with at least one acid having a weak nucleophilic anion; and optionally B) a catalytic amount of a catalyst useful for accelerating the reaction of a polyepoxide with the curing agent, wherein the inhibitor and catalyst may be present in complex form.

  总之，本申请涉及一类化合物的发现，该化合物由硼酸或马来酸或硼酸与至少一种具有弱亲核阴离子的酸的混合物组成，在低温下可抑制聚环氧化物与固化剂的反应。在另一个实施方案中，本申请涉及一种潜伏催化剂系统，该系统适用于固化聚环氧乙烷，该固化聚环氧乙烷化合物的催化剂包括胺、杂环含氮膦、硫化物、膦、硫化物、铵、鏻、锍、胂、含化合物或其混合物；与 I) 硼酸或硼酸与至少一种具有弱亲核阴离子的酸的混合物接触后产生的聚环氧乙烷。此外，本申请还涉及含有抑制剂或潜在催化成分的环氧树脂组合物。在另一个实施方案中，本申请涉及一种用于固化聚环氧树脂的组合物，该组合物含有A) 抑制量的硼酸或马来酸或硼酸与至少一种具有弱亲核阴离子的酸的混合物；以及 B) 催化量的催化剂，用于加速聚环氧化物与固化剂的反应，其中抑制剂和催化剂可以复合物形式存在。