3-乙基环丁烷羰基氯化物 | 76730-61-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 中文名称: 3-乙基环丁烷羰基氯化物
• 英文名称: 3-ethylcyclobutanecarboxylic acid chloride
• 英文别名: 3-ethylcyclobutane-1-carbonyl chloride
• CAS: 76730-61-5
• 化学式: C₇H₁₁ClO
• 分子量: 146.617
• InChiKey: PXCMZBDFAWHSSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-乙基环丁烷羰基氯化物 在 吡啶 、 lithium aluminium tetrahydride 作用下， 以 乙醚 、 二甲基亚砜 为溶剂， 反应 3.5h， 生成 (3-Ethyl-cyclobutyl)-acetonitrile
  参考文献：
  名称：

  Chan, L. K. M.; Gemmell, P. A.; Gray, G. W., Molecular Crystals and Liquid Crystals (1969-1991), 1989, vol. 168, p. 229 - 246

  摘要：

  DOI：
• 作为产物：
  描述：

  2-乙基-1,3-丙二醇 在 吡啶 、 氢氧化钾 、 氯化亚砜 、 sodium hydride 作用下， 以 1,4-二氧六环 为溶剂， 生成 3-乙基环丁烷羰基氯化物
  参考文献：
  名称：

  Chan, L. K. M.; Gemmell, P. A.; Gray, G. W., Molecular Crystals and Liquid Crystals (1969-1991), 1989, vol. 168, p. 229 - 246

  摘要：

  DOI：

文献信息

• Cyclobutyl substituted derivatives of prostaglandin analogs
  申请人：Miles Laboratories, Inc.

  公开号：US04220795A1

  公开（公告）日：1980-09-02

  Novel C15 cyclobutyl analogs or derivatives of prostaglandins of the E-, A- and F-classes are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties such as platelet antiaggregating agents, gastric antisecretory agents and brochodilating agents.

  新型C15环丁基类前列腺素的衍生物或类似物在调节平滑肌活动方面具有用途。这些化合物具有宝贵的药理特性，如抗血小板聚集剂、胃抗分泌剂和支气管扩张剂。
• Cyclobutanecarboxylic acid derivatives and liquid crystalline
  申请人：Kanto Kagaku Kabushiki Kaisha

  公开号：US05545747A1

  公开（公告）日：1996-08-13

  An optically inactive cyclobutanecarboxylic acid derivative of the general formula ##STR1## wherein R.sup.1 is a hydrogen atom or a straight or branched chain alkyl group having 1-14 carbon atoms, R.sup.2 is a straight or branched chain alkyl group having 1-14 carbon atoms, X.sup.1 and X.sup.2 independently represent hydrogen or fluorine atoms, as well as a liquid crystalline composition containing at least one such derivative.

  一种光学上不活性的环丁烷羧酸衍生物，其通式为##STR1##其中R.sup.1是氢原子或具有1-14个碳原子的直链或支链烷基基团，R.sup.2是具有1-14个碳原子的直链或支链烷基基团，X.sup.1和X.sup.2分别代表氢或氟原子，以及含有至少一种这种衍生物的液晶组合物。
• CYCLOBUTANECARBOXYLIC ACID DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME
  申请人：KANTO KAGAKU KABUSHIKI KAISHA

  公开号：EP0496896A1

  公开（公告）日：1992-08-05

  An optically inactive cyclobutanecarboxylic acid derivative represented by general formula (I) and a liquid crystal composition containing at least one such derivative wherein R¹ represents hydrogen or C₁ to C₁₄ linear or branched alkyl; R² represents C₁ to C₁₄ linear or branched alkyl; and X¹ and X² represent each hydrogen or fluorine.

  通式(I)代表的光学不活泼环丁烷羧酸衍生物和含有至少一种此类衍生物的液晶组合物 其中 R¹ 代表氢或 C₁ 至 C₁₄ 直链或支链烷基；R² 代表 C₁ 至 C₁₄ 直链或支链烷基；X¹ 和 X² 各自代表氢或氟。
• Long-acting contraceptive agents: Design of the who chemical synthesis programme
  作者：Pierre Crabbé、Sydney Archer、Giuseppe Benagiano、Egon Diczfalusy、Carl Djerassi、Josef Fried、Takeru Higuchi

  DOI：10.1016/0039-128x(83)90095-8

  日期：1983.3

  The great demand for improved long-acting injectable steroid contraceptives, particularly in developing countries, and the relative lack of interest from the pharmaceutical industry to develop such products stimulated WHO to launch a synthetic and screening programme to find improved, safe and acceptable injectable preparations. More than 210 esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) and levonorgestrel (D-(-)-13 beta-ethyl-17 alpha-ethynyl-17 beta-hydroxygon-4-en-3-one) have been prepared in university-based research laboratories situated mainly in developing countries, and then screened by NICHHD in animal models. The following three compounds, levonorgestrel butanoate, cyclopropylcarboxylate and cyclobutylcarboxylate, proved to be particularly long-acting when administered as microcrystalline suspensions. The overall strategy of this research and development programme is described.
• US4220795A
  申请人：——

  公开号：US4220795A

  公开（公告）日：1980-09-02