3-二乙基氨基丙肼 | 83742-04-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-二乙基氨基丙肼
• 英文名称: β-Diethylaminopropionhydrazid
• 英文别名: 3-(Diethylamino)propanehydrazide
• CAS: 83742-04-5
• 化学式: C₇H₁₇N₃O
• mdl: MFCD05267739
• 分子量: 159.231
• InChiKey: FAXGCFPTKUTKRD-UHFFFAOYSA-N

物化性质

• 溶解度：
  16.4 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  58.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  3-二乙基氨基丙肼 在 盐酸 、 sodium nitrate 作用下， 以 水 为溶剂， 反应 7.0h， 以83%的产率得到N,N-二乙基乙二胺
  参考文献：
  名称：

  Yao, Ri-Sheng; Jiang, Lai-En; Wu, Sheng-Hua, Asian Journal of Chemistry, 2011, vol. 23, # 9, p. 3792 - 3794

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(二乙基氨基)丙酸甲酯 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以95%的产率得到3-二乙基氨基丙肼
  参考文献：
  名称：

  Yao, Ri-Sheng; Jiang, Lai-En; Wu, Sheng-Hua, Asian Journal of Chemistry, 2011, vol. 23, # 9, p. 3792 - 3794

  摘要：

  DOI：

文献信息

• Synthesis of aliphatic amino-acid hydrazides as potential tuberculostatic agents
  作者：D Edwards、D Hamer、W H Stewart

  DOI：10.1111/j.2042-7158.1964.tb07521.x

  日期：2011.4.12

  Some dialkylamino-aliphatic acid hydrazides and bis(hydrazinocarbonyl) compounds have been prepared and tested for antituberculosis activity. None of these compounds was found to possess tuberculostatic activity of the same order as that of isoniazid.

  摘要 一些二烷基氨基脂肪酸肼和双(肼甲酰基)化合物已经制备并测试其抗结核活性。这些化合物中没有发现任何一种具有与异烟肼相同级别的抗结核活性。
• MODIFIED NATURAL RUBBER, PROCESS FOR PRODUCTION OF THE SAME, AND RUBBER COMPOSITION AND TIRE EACH COMPRISING THE SAME
  申请人：Bridgestone Corporation

  公开号：EP2206730A1

  公开（公告）日：2010-07-14

  This invention provides a modified natural rubber producible at a lower cost than the conventional techniques and capable of improving the low loss factor, wear resistance and fracture characteristics of the rubber composition using the modified natural rubber as the rubber component in the rubber composition, and a method for producing the modified natural rubber. This invention provides a modified natural rubber formed by adding a hydrazide compound having a polar group to at least one natural rubber raw material selected from the group consisting of a natural rubber, a coagulated natural rubber latex and a natural rubber cup lump, a rubber composition using the modified natural rubber, and a tire using the rubber composition in any tire member.

  本发明提供了一种改性天然橡胶，其生产成本低于传统技术，并且能够改善橡胶组合物的低损耗因子、耐磨性和断裂特性，橡胶组合物中使用改性天然橡胶作为橡胶成分，本发明还提供了一种生产改性天然橡胶的方法。本发明提供了一种通过向至少一种天然橡胶原料添加具有极性基团的酰肼化合物而形成的改性天然橡胶，该天然橡胶原料选自天然橡胶、凝固天然橡胶胶乳和天然橡胶杯状胶块组成的组，还提供了一种使用改性天然橡胶的橡胶组合物，以及一种在任何轮胎部件中使用该橡胶组合物的轮胎。
• Development of Nonpeptidic Inverse Agonists of the Ghrelin Receptor (GHSR) Based on the 1,2,4-Triazole Scaffold
  作者：Khoubaib Ben Haj Salah、Mathieu Maingot、Anne-Laure Blayo、Céline M’Kadmi、Marjorie Damian、Sophie Mary、Sonia Cantel、Jérémie Neasta、Catherine Oiry、Sylvie Péraldi-Roux、Gimena Fernandez、Guadalupe García Romero、Mario Perello、Jacky Marie、Jean-Louis Banères、Jean-Alain Fehrentz、Séverine Denoyelle

  DOI：10.1021/acs.jmedchem.9b02122

  日期：2020.10.8

  GHSR controls, among others, growth hormone and insulin secretion, adiposity, feeding, and glucose metabolism. Therefore, an inverse agonist ligand capable of selectively targeting GHSR and reducing its high constitutive activity appears to be a good candidate for the treatment of obesity-related metabolic diseases. In this context, we present a study that led to the development of several highly potent and selective inverse agonists of GHSR based on the 1,2,4-triazole scaffold. We demonstrate that, depending on the nature of the substituents on positions 3, 4, and 5, this scaffold leads to ligands that exert an intrinsic inverse agonist activity on GHSR-catalyzed G protein activation through the stabilization of a specific inactive receptor conformation. Thanks to an in vivo evaluation, we also show that one of the most promising ligands not only exerts an effect on insulin secretion in rat pancreatic islets but also affects the orexigenic effects of ghrelin in mice.
• MODIFIED DIENE RUBBER, METHOD FOR PRODUCING THE SAME, RUBBER COMPOSITION USING THE SAME, AND TIRE
  申请人：Bridgestone Corporation

  公开号：EP2248833B1

  公开（公告）日：2014-03-26
• MODIFIED NATURAL RUBBER AND METHOD FOR PRODUCING SAME, AND RUBBER COMPOSITION AND TIRE USING SUCH A MODIFIED NATURAL RUBBER
  申请人：Yonemoto Makiko

  公开号：US20100249336A1

  公开（公告）日：2010-09-30

  This invention provides a modified natural rubber producible at a lower cost than the conventional techniques and capable of improving the low loss factor, wear resistance and fracture characteristics of the rubber composition using the modified natural rubber as the rubber component in the rubber composition, and a method for producing the modified natural rubber. This invention provides a modified natural rubber formed by adding a hydrazide compound having a polar group to at least one natural rubber raw material selected from the group consisting of a natural rubber, a coagulated natural rubber latex and a natural rubber cup lump, a rubber composition using the modified natural rubber, and a tire using the rubber composition in any tire member.