3,6-Diethyl-3,6-dihexyl-[1,2,4,5]tetroxane | 914917-07-0

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机氧化物
• 英文名称: 3,6-Diethyl-3,6-dihexyl-[1,2,4,5]tetroxane
• 英文别名: 3,6-Diethyl-3,6-dihexyl-1,2,4,5-tetroxane；3,6-diethyl-3,6-dihexyl-1,2,4,5-tetraoxane
• CAS: 914917-07-0
• 化学式: C₁₈H₃₆O₄
• 分子量: 316.481
• InChiKey: AGPAWRJABNUYPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  22
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-壬酮 在 tetrafluoroboric acid 、 双氧水 、 甲基三氧化铼(VII) 作用下， 以 乙醚 、 2,2,2-三氟乙醇 、 水 为溶剂， 反应 1.0h， 以55%的产率得到3,6-Diethyl-3,6-dihexyl-[1,2,4,5]tetroxane
  参考文献：
  名称：

  Synthesis and antimalarial activities of novel 3,3,6,6-tetraalkyl-1,2,4,5-tetraoxanes

  摘要：

  The oxidative system H2O2/fluorinated alcohol (TFE, HF1P) was used for direct acid- and MeRCO3-catalyzed synthesis of 1,2,4,5-tetraoxanes from cyclic (C6, C7, and C12) and acyclic ketones. The influence of ring size and alkyl chain length were studied and antimalarial activities of synthetic 3,3,6,6-tetraalkyl-1,2,4,5-tetraoxanes were determined. Variations in their antimalarial activities were significant, although they share similar electrochemical properties of the peroxide bond. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.07.069

文献信息

• Synthesis and antimalarial activities of novel 3,3,6,6-tetraalkyl-1,2,4,5-tetraoxanes
  作者：Katja Žmitek、Stojan Stavber、Marko Zupan、Daniele Bonnet-Delpon、Sebastien Charneau、Phillipe Grellier、Jernej Iskra

  DOI：10.1016/j.bmc.2006.07.069

  日期：2006.12

  The oxidative system H2O2/fluorinated alcohol (TFE, HF1P) was used for direct acid- and MeRCO3-catalyzed synthesis of 1,2,4,5-tetraoxanes from cyclic (C6, C7, and C12) and acyclic ketones. The influence of ring size and alkyl chain length were studied and antimalarial activities of synthetic 3,3,6,6-tetraalkyl-1,2,4,5-tetraoxanes were determined. Variations in their antimalarial activities were significant, although they share similar electrochemical properties of the peroxide bond. (c) 2006 Elsevier Ltd. All rights reserved.