3-Methylene-2,3-dihydroisoquinoline | 74488-22-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢异喹啉
• 英文名称: 3-Methylene-2,3-dihydroisoquinoline
• 英文别名: 3-methylidene-2H-isoquinoline
• CAS: 74488-22-5
• 化学式: C₁₀H₉N
• 分子量: 143.18
• InChiKey: VRXZJOHXJJTEPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Therapeutic Compounds 570
  申请人：Bayrakdarian Malken

  公开号：US20090099195A1

  公开（公告）日：2009-04-16

  Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R 1 , R 2 , R 3 , R 4 , and R 5 and are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

  公式I的化合物或其药学上可接受的盐：其中R1、R2、R3、R4和R5如规范中所定义，以及制备包括这些化合物的盐和药物组合物。它们在治疗中有用，特别是在疼痛管理方面。
• NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE HAVING 2-IMINO GROUP AND PEST CONTROL AGENT INCLUDING THE SAME
  申请人：MEIJI SEIKA PHARMA CO., LTD.

  公开号：US20150005347A1

  公开（公告）日：2015-01-01

  Provided is a nitrogen-containing heterocyclic derivative having a 2-imino group, which is represented by the following Formula (I). [in the formula, Ar represents a phenyl group which may be substituted, a 5- to 6-membered heterocycle which may be substituted, or a 4- to 10-membered heterocycloalkyl group, A represents a heterocycle having a 5- to 10-membered unsaturated bond including one or more nitrogen atoms, and has an imino group substituted with an R group at a position adjacent to the nitrogen atom present on the cycle, Y represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1 to C6 alkyl group which may be substituted with a halogen atom, a C1 to C6 alkyloxy group which may be substituted with a halogen atom, a cyano group, or a nitro group, and R represents any one of groups represented by the following Formulae (a) to (e), (y) or (z).]

  提供的是一种含氮杂环衍生物，具有2-亚氨基基团，其化学式如下（I）所示。[在该式中，Ar代表可能被取代的苯基，可能被取代的5-至6-元杂环或4-至10-元杂环烷基基团，A代表含有5-至10-元不饱和键的杂环，其中包括一个或多个氮原子，并且在环上存在一个邻位于氮原子处的被R基取代的亚氨基，Y代表氢原子、卤素原子、羟基、可能被卤素原子取代的C1至C6烷基、可能被卤素原子取代的C1至C6烷氧基、氰基或硝基，R代表以下化学式（a）至（e）、（y）或（z）中的任意一种基团。]
• PEST CONTROL COMPOSITION INCLUDING NOVEL IMINOPYRIDINE DERIVATIVE
  申请人：MEIJI SEIKA PHARMA CO., LTD.

  公开号：US20140315839A1

  公开（公告）日：2014-10-23

  Provided is a pest control composition containing a novel iminopyridine derivative and other pest control agents. Provided is a pest control composition containing an iminopyridine derivative represented by the following Formula (I) and at least one of other pest control agents: [in the formula (I), Ar represents a 5- to 6-membered heterocycle which may be substituted, A represents a heterocycle having a 5- to 10-membered unsaturated bond including one or more nitrogen atoms, and has an imino group substituted with an R group at a position adjacent to the nitrogen atom present on the cycle, Y represents hydrogen, halogen and the like, and R represents any one of groups represented by the following Formulae (a) to (e), (y) or (z)].

  提供了一种杀虫组合物，包含一种新的亚胺吡啶衍生物和其他杀虫剂。提供了一种杀虫组合物，其中包含由以下式子（I）表示的亚胺吡啶衍生物和至少一种其他杀虫剂：[在式子（I）中，Ar表示一种5-至6-成员的杂环，可以被取代，A表示具有5-至10-成员不饱和键的杂环，包括一个或多个氮原子，并在循环上存在一个邻位氮原子上的R基取代的亚胺基团，Y表示氢，卤素等，R表示以下式子（a）至（e）、（y）或（z）中的任意一种基团。]
• Pest control composition including novel iminopyridine derivative
  申请人：MEIJI SEIKA PHARMA CO., LTD.

  公开号：US10349655B2

  公开（公告）日：2019-07-16

  Provided is a pest control composition containing a novel iminopyridine derivative and other pest control agents. Provided is a pest control composition containing an iminopyridine derivative represented by the following Formula (I) and at least one of other pest control agents: [in the formula (I), Ar represents a 5- to 6-membered heterocycle which may be substituted, A represents a heterocycle having a 5- to 10-membered unsaturated bond including one or more nitrogen atoms, and has an imino group substituted with an R group at a position adjacent to the nitrogen atom present on the cycle, Y represents hydrogen, halogen and the like, and R represents any one of groups represented by the following Formulae (a) to (e), (y) or (z)].

  本发明提供了一种含有新型亚氨基吡啶衍生物和其他害虫防治剂的害虫防治组合物。 本发明提供了一种害虫防治组合物，其中含有由下式（I）代表的亚胺吡啶衍生物和至少一种其他害虫防治剂： [在式 (I) 中，Ar 代表可被取代的 5 至 6 元杂环，A 代表具有 5 至 10 元不饱和键的杂环，包括一个或多个氮原子，并在邻近环上氮原子的位置具有被 R 基取代的亚氨基，Y 代表氢、卤素等，R 代表下式 (a) 至 (e)、(y) 或 (z) 所代表的任何一个基团]。
• Nitrogen-containing heterocyclic derivate having 2-imino group and pest control agent including the same
  申请人：Meiji Seika Pharma Co., Ltd.

  公开号：EP2634174B1

  公开（公告）日：2017-05-17