4-aminoantipyrine | 760187-21-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-aminoantipyrine
• 英文别名: 3-Amino-2,4-dimethyl-1-phenyl-3-pyrazolin-5-on；5-amino-1,4-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one；5-Amino-1,4-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-on；5-Amino-1,4-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one；5-amino-1,4-dimethyl-2-phenylpyrazol-3-one
• CAS: 760187-21-1
• 化学式: C₁₁H₁₃N₃O
• 分子量: 203.244
• InChiKey: ZPWUSPNWEVEVDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  49.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-aminoantipyrine 、 靛红 以 乙醇 为溶剂， 生成 3-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)imino-1,3-dihydro-2H-indol-2-one
  参考文献：
  名称：

  4-Aminoantipyrine-based Schiff-base transition metal complexes as potent anticonvulsant agents

  摘要：

  Metal complexes of Co(II), Ni(II), Cu(II), and Zn(II) with ligands ((LH)-H-1 and L-2) derived from 4-aminoantipyrine, 2-hydroxy-3-formylquinoline, and isatin were synthesized and characterized by the elemental analysis, conductance measurements, magnetic susceptibility, and spectral analysis. The spectral data revealed that the ligands acted as a neutral tridentate, coordinating to the metal ion through the azomethine nitrogen, phenolic oxygen, and carbonyl oxygen of the 4-aminoantipyrine, 2-hydroxy-3-formylquinoline, and isatin molecule in ligands (LH)-H-1 and L-2 only. Both the ligands and their metal complexes were studied for cyclic voltammetry studies. The ligand and the metal complexes were screened for their anticonvulsant activity, and it has been observed that the metal complexes are more potent than the ligands.

  DOI：

  10.1007/s00044-011-9749-3
• 作为产物：
  描述：

  (2,4-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-3-yl)-carbamic acid isopropyl ester 在 sodium hydroxide 、 水 作用下， 生成 4-aminoantipyrine
  参考文献：
  名称：

  DE747473

  摘要：

  公开号：