3-异丙基-6-(2-甲基-丙基)-2,5-哌嗪二酮 | 5625-50-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-异丙基-6-(2-甲基-丙基)-2,5-哌嗪二酮
• 中文别名: 环-(亮氨酸-缬氨酸)二肽
• 英文名称: cyclo-(Leu-Val)
• 英文别名: 3-isobutyl-6-isopropyl-piperazine-2,5-dione；3-Isobutyl-6-isopropyl-piperazin-2,5-dion；3-Isobutyl-6-isopropyl-2,5-dioxo-piperazin (Valyl-leucyl-anhydrid)；2,5-Dioxo-3-isopropyl-6-isobutyl-piperazin；3-Isopropyl-6-(2-methyl-propyl)-2,5-piperazinedione；3-(2-methylpropyl)-6-propan-2-ylpiperazine-2,5-dione
• CAS: 5625-50-3
• 化学式: C₁₁H₂₀N₂O₂
• 分子量: 212.292
• InChiKey: UPOUGDHEEGKEGS-UHFFFAOYSA-N

物化性质

• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  DL-亮氨酰-DL-缬氨酸 在 二苯胺 作用下， 生成 3-异丙基-6-(2-甲基-丙基)-2,5-哌嗪二酮
  参考文献：
  名称：

  Abderhalden; Gebelein, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1926, vol. 152, p. 131

  摘要：

  DOI：

文献信息

• COMPOUNDS AND METHODS FOR MODULATING COMMUNICATION AND VIRULENCE IN QUORUM SENSING BACTERIA
  申请人：BLACKWELL Helen E.

  公开号：US20100305182A1

  公开（公告）日：2010-12-02

  The present invention provides compositions and methods for modulating the communication and virulence of quorum sensing bacteria. In various exemplary embodiments, the invention provides a combinatorial library of quorum sensing compounds including synthetic analogs of naturally occurring and non-naturally occurring acyl-homoserine lactone (AHL) analogs, and methods of synthesizing and using these compounds.

  本发明提供了调节群体感应细菌的通讯和毒力的组合物和方法。在各种示例实施方案中，本发明提供了一种群体感应化合物的组合库，包括天然存在和非天然存在的酰基-同型半乳糖内酯（AHL）类似物的合成类似物，以及这些化合物的合成和使用方法。
• Solution casting method and polymer film
  申请人：Sugiura Masaru

  公开号：US20050077648A1

  公开（公告）日：2005-04-14

  A solvent in which dichloromethane is mixed with alcohol as a poor solvent is used for preparing a dope. Alcohol is supplied to the dope in a inline pipe to mix with a static mixer, such as a casting dope in which a composition of alcohol is increased. The temperature of the rotary drum is adjusted to −7° C. The casting dope is fed from a casting die to the rotary drum so as to form a casting film whose thickness is 40 μm. Since the content of alcohol is high and a storage modulus of the cooled casting film is at least 150 thousands Pa, the peeling defect does not occur, and the stretch is reduced as far as possible. A gel-like film is dried by a tenter type drying device, and stretched such that the stretch ratio is at most 110%. The produced film is thin and excellent in a surface condition and optical isotropy.

  二氯甲烷与作为劣质溶剂的酒精混合的溶剂用于制备涂料。酒精通过内联管道供应到涂料中，与静态混合器混合，如增加酒精成分的铸造涂料。将浇注料从浇注模具送入旋转滚筒，以形成厚度为 40 μm 的浇注膜。由于酒精含量高，冷却后的浇注膜的储存模量至少为 15 万帕，因此不会出现剥离缺陷，拉伸也尽可能减小。凝胶状薄膜由拉幅机干燥，拉伸率不超过 110%。生产出的薄膜很薄，表面状态和光学各向同性都很好。
• Maillard, Annales de Chimie (Cachan, France), 1915, vol. <9> 4, p. 246,247, 248, 251
  作者：Maillard

  DOI：——

  日期：——
• Davis, Annales de Chimie (Cachan, France), 1954, vol. <12> 9, p. 399,426
  作者：Davis

  DOI：——

  日期：——
• Fischer,E.; Scheibler, Justus Liebigs Annalen der Chemie, 1908, vol. 363, p. 158,159
  作者：Fischer,E.、Scheibler

  DOI：——

  日期：——