3-(4,5-Dimethylthiazole-2-yl)-2,5-diphenyltetrazolium chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(4,5-Dimethylthiazole-2-yl)-2,5-diphenyltetrazolium chloride
• 英文别名: 2-(2,5-diphenyl-1H-tetrazol-1-ium-3-yl)-4,5-dimethyl-1,3-thiazole;chloride
• 化学式: C18H18ClN5S
• 分子量: 371.9
• InChiKey: KYENMFWIKMBWJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.15
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  76.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Analytical method using tetrazolium salt indicators having a reflectance plateau
  申请人：Bayer Corporation

  公开号：EP0476454A1

  公开（公告）日：1992-03-25

  General classes of 2-thiazolyl tetrazolium salt compounds have been found to be characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

  已发现 2-噻唑基四唑盐化合物的一般类别具有反射光谱的特征，即在大约 600-650 纳米波长以上有一个扩展的高原。此类化合物可用作还原性物质（如 NADH）的发色性指示剂。反射高原提高了分析测定的准确性，特别是在测定具有医疗诊断意义的分析物时，其中试剂载体基质上的比色反应是通过反射测定的。
• Substituted 2-thiazolyl tetrazolium salt indicators
  申请人：Bayer Corporation

  公开号：EP0476456A2

  公开（公告）日：1992-03-25

  2-Thiazolyl tetrazolium salt compounds characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

  2-Thiazolyl tetrazolium salt（2-噻唑基四氮唑盐）化合物，其特征是反射光谱在约 600-650 纳米波长以上表现出延伸的高原。此类化合物可用作还原性物质（如 NADH）的显色指示剂。反射高原提高了分析测定的准确性，特别是在测定具有医疗诊断意义的分析物时，其中试剂载体基质上的比色反应是通过反射测定的。
• 2-Benzothiazolyl tetrazolium salt indicators
  申请人：Bayer Corporation

  公开号：EP0476457A2

  公开（公告）日：1992-03-25

  2-Benzothiazolyl tetrazolium salt compounds have been found to be characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

  研究发现，2-苯并噻唑基四唑鎓盐化合物的反射光谱在大约 600-650 纳米波长以上有一个延伸的高原。这种化合物可用作还原性物质（如 NADH）的显色指示剂。反射高原提高了分析测定的准确性，特别是在测定具有医疗诊断意义的分析物时，其中试剂载体基质上的比色反应是通过反射测定的。
• Acyl carnitine esterase, production thereof and method for analyzing acyl carnitines
  申请人：ASAHI KASEI KOGYO KABUSHIKI KAISHA

  公开号：EP0480676A2

  公开（公告）日：1992-04-15

  An acylcarnitine esterase which has a substrate specificity to acyl-L-carnitines including short chain acyl-L-carnitines inclusive of acetyl-L-carnitine and propionyl-L-carnitine and which catalyzes the hydrolysis reaction of one mole of the acyl-L-carnitines with one mole of water to form one mole of the corresponding fatty acid and one mole of L-carnitine.

  一种酰基肉碱酯酶，它对酰基-L-肉碱（包括乙酰基-L-肉碱和丙酰基-L-肉碱在内的短链酰基-L-肉碱）具有底物特异性，可催化一摩尔酰基-L-肉碱与一摩尔水的水解反应，生成一摩尔相应的脂肪酸和一摩尔 L-肉碱。
• Diagnosis of candida vaginitis by detecting d-arabinitol in vaginal fluid
  申请人：MILES INC.

  公开号：EP0556725A2

  公开（公告）日：1993-08-25

  A method for the presumptive detection of Candida in vaginal fluid, thereby providing an aid to the diagnosis of Candida vaginosis. A sample of vaginal fluid is combined with a test composition comprising an indicator system that provides a chromogenic response in the presence of D-arabinitol; the detection of an elevated level of D-arabinitol indicating the presumptive presence of Candida. The test composition preferably comprises the enzyme D-arabinitol dehydrogenase, NAD, an electron transfer agent, and a chromogenic indicator.

  一种推定检测阴道液中念珠菌的方法，从而为诊断念珠菌性阴道病提供帮助。将阴道液样本与检测组合物结合，检测组合物包含一个指示剂系统，该指示剂系统在 D-阿拉伯糖醇存在的情况下会产生发色反应；检测到 D-阿拉伯糖醇水平升高，则表明推定存在念珠菌。检测组合物最好由 D-阿拉伯糖醇脱氢酶、NAD、电子传递剂和发色指示剂组成。