3-氨基-3-(2-氟苯基)丙酸 | 117391-49-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-氨基-3-(2-氟苯基)丙酸
• 中文别名: (RS)-3-氨基-3-(2-氟苯基)丙酸；3-氨基-3-(2-氟苯基)-丙酸
• 英文名称: 3-amino-3-(2-fluorophenyl)propanoic acid
• 英文别名: 3-azaniumyl-3-(2-fluorophenyl)propanoate
• CAS: 117391-49-8
• 化学式: C₉H₁₀FNO₂
• mdl: MFCD00193241
• 分子量: 183.182
• InChiKey: RSCLTSJQAQBNCE-UHFFFAOYSA-N

物化性质

• 熔点：
  222-224
• 沸点：
  302.6±32.0 °C(Predicted)
• 密度：
  1.289±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 海关编码：
  2922499990
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  室温且干燥

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 3-Amino-3-(2-fluorophenyl)propanoic acid
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 3-Amino-3-(2-fluorophenyl)propanoic acid
CAS number: 117391-49-8

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C9H10FNO2
Molecular weight: 183.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3-氨基-3-(2-氟苯基)丙酸 在 硫酸 、 硝酸 、 碳酸氢钠 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 alloc-3-amino-3-(2-fluoro-5-nitrophenyl)propionic acid
  参考文献：
  名称：

  使用四功能支架轻松固相合成1,2-二取代-6-硝基-1,4-二氢喹唑啉

  摘要：

  描述了1，2-二取代的6-硝基-1，4-二氢喹唑啉的固相合成。通过硝化3-氨基-3-（2-氟苯基）丙酸制备了新的四官能支架N -Alloc-3-氨基-3-（2-氟-5-硝基苯基）丙酸。支架通过其羧基固定在Rink树脂上，并用伯胺处理以取代芳基氟，然后在DIC存在下，在Alloc脱保护的情况下在DIC存在下用芳基异硫氰酸酯环化，得到1,2-二取代-6-硝基-1,4-高产二氢喹唑啉。

  DOI：

  10.1016/j.tetlet.2004.11.095
• 作为产物：
  描述：

  丙二酸 、 2-氟苯甲醛 在 ammonium acetate 作用下， 以 乙醇 为溶剂， 生成 3-氨基-3-(2-氟苯基)丙酸
  参考文献：
  名称：

  使用四功能支架轻松固相合成1,2-二取代-6-硝基-1,4-二氢喹唑啉

  摘要：

  描述了1，2-二取代的6-硝基-1，4-二氢喹唑啉的固相合成。通过硝化3-氨基-3-（2-氟苯基）丙酸制备了新的四官能支架N -Alloc-3-氨基-3-（2-氟-5-硝基苯基）丙酸。支架通过其羧基固定在Rink树脂上，并用伯胺处理以取代芳基氟，然后在DIC存在下，在Alloc脱保护的情况下在DIC存在下用芳基异硫氰酸酯环化，得到1,2-二取代-6-硝基-1,4-高产二氢喹唑啉。

  DOI：

  10.1016/j.tetlet.2004.11.095

文献信息

• Design, synthesis and structure-activity relationship of a focused library of β-phenylalanine derivatives as novel eEF2K inhibitors with apoptosis-inducing mechanisms in breast cancer
  作者：Yongzhi Guo、Yuqian Zhao、Guan Wang、Yi Chen、Yingnan Jiang、Liang Ouyang、Bo Liu

  DOI：10.1016/j.ejmech.2017.11.065

  日期：2018.1

  many types of cancer; therefore, eEF2K would be regarded as a promising therapeutic target. In this study, we discovered a β-phenylalanine scaffold by virtual high-throughput screening, as well as designed and synthesized 46 derivatives with assessment of inhibition activity against eEF2K and cytotoxicity. After several rounds of kinase and anti-proliferative activity screening, we discovered an eEF2K

  真核延伸因子2激酶（eEF2K）是一种Ca2 + /钙调蛋白依赖性蛋白激酶，属于非典型Ser / Thr蛋白激酶的小家族。最近有报道称eEF2K在许多类型的癌症中被高度激活或过表达。因此，eEF2K被认为是有希望的治疗靶标。在这项研究中，我们通过虚拟高通量筛选发现了β-苯丙氨酸支架，并设计和合成了46种衍生物，评估了其对eEF2K的抑制活性和细胞毒性。经过几轮激酶和抗增殖活性筛选后，我们发现了具有最佳eEF2K酶促活性（IC50为5.5μM）和抗增殖活性（MDA-MB-231细胞，IC50为12.6μM，MDA）的eEF2K抑制剂（21l） -MB-436细胞，IC50为19.8μM。而且，我们发现21l可以通过MDA-MB-231和MDA-MB-436细胞的凋亡途径诱导细胞死亡。随后，我们评估了其在体内的抗肿瘤活性和诱导细胞凋亡的机制。这些结果表明21l通过在乳腺癌的异种移植小鼠模型（M
• [EN] 4 -HYDROXY- ISOQUINOLINE COMPOUNDS AS HIF HYDROXYLASE INHIBITORS<br/>[FR] COMPOSÉS 4-HYDROXY-ISOQUINOLÉINE COMME INHIBITEURS D'HYDROXYLASE HIF
  申请人：FIBROGEN INC

  公开号：WO2013134660A1

  公开（公告）日：2013-09-12

  The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. The invention also relates to compounds of formula (I) for use in disorders such as muscle degeneration, colitis, IBD, and certain ischemias.

  本发明涉及式(I)的新化合物，以及能够选择性地抑制PHD1酶活性而不影响其他同工酶（例如PHD2和/或PHD3酶）的组合物。该发明还涉及式(I)的化合物在肌肉退化、结肠炎、炎症性肠病和某些缺血症等疾病中的应用。
• Influence of the aromatic moiety in α- and β-arylalanines on their biotransformation with phenylalanine 2,3-aminomutase from Pantoea agglomerans
  作者：Andrea Varga、Gergely Bánóczi、Botond Nagy、László Csaba Bencze、Monica Ioana Toşa、Ákos Gellért、Florin Dan Irimie、János Rétey、László Poppe、Csaba Paizs

  DOI：10.1039/c6ra02964g

  日期：——

  isomerization of various racemic α- and β-arylalanines catalysed by phenylalanine 2,3-aminomutase from Pantoea agglomerans (PaPAM) was investigated. Both α- and β-arylalanines were accepted as substrates when the aryl moiety was relatively small, like phenyl, 2-, 3-, 4-fluorophenyl or thiophen-2-yl. While 2-substituted α-phenylalanines bearing bulky electron withdrawing substituents did not react, the corresponding

  在这项研究中，Pantoea agloglomerans的苯丙氨酸2，3-氨基变位酶催化的各种外消旋α-和β-芳基丙氨酸的对映异构体选择性异构化（PaPAM）进行了调查。当芳基部分相对较小时，如苯基，2-，3-，4-氟苯基或噻吩-2-基，α-和β-芳基丙氨酸均被接受为底物。尽管带有大量吸电子取代基的2-取代的α-苯丙氨酸没有反应，但相应的取代的β-芳基类似物却被迅速转化。3-和4-取代的α-芳基丙氨酸的转化顺利进行，而相应的β-芳基丙氨酸的转化不良或不存在。在pH 7-9范围内，对外消旋α-或β-（噻吩-2-基）丙氨酸的转化率没有明显影响，而氨的浓度（碳酸铵从50 mM增加到1000 mM）则抑制了异构化逐步减少副产物的量（即（E检测到）-3-（噻吩-2-基）丙烯酸。在所有情况下，产物的高ee值表明优异的对映异构体选择性和异构化的立体特异性，除了来自β-异构体的（S）-2-硝基-α-苯丙氨酸（ee
• Kinetic Resolution of Aromatic β-Amino Acids Using a Combination of Phenylalanine Ammonia Lyase and Aminomutase Biocatalysts
  作者：Nicholas J. Weise、Syed T. Ahmed、Fabio Parmeggiani、Nicholas J. Turner

  DOI：10.1002/adsc.201600894

  日期：2017.5.2

  linked to the first ever proposed biosynthesis of pyloricidin‐like secondary metabolites and was shown to display better β‐lyase activity in many cases. In spite of this, a method combining the higher conversion of EncP with a strict α‐lyase from Anabaena variabilis (AvPAL) was found to be more amenable, allowing kinetic resolution of five racemic substrates and a preparative‐scale reaction with >98% (R)

  已经证明了使用苯丙氨酸氨基变位酶和氨裂合酶（PAM和PAL）酶制备（R）-β-芳基丙氨酸的酶促策略。具有海马链霉菌（EncP）和芽孢杆菌（Bacillus sp。）选择性（S）选择性的候选PAM 。（PabH）通过使用充分研究的模板序列进行序列分析来鉴定。新发现的PabH可能与首次提出的幽门螺杆菌样二级代谢产物的生物合成有关，并在许多情况下显示出更好的β-裂合酶活性。尽管如此，ENCP的较高的转化率具有严格α -裂解酶合成的方法从多变鱼腥藻（AvPAL）被认为是更合适的，它允许五种外消旋底物的动力学拆分以及制备规模的对映体过量> 98％（R）的反应。这项工作代表了对现有生物催化策略的一种改进和对映体互补的方法，它允许简单的产品分离和模块化的伸缩组合，以及使用非手性醛作为原料的先前化学步骤。
• Configurationally Stable (<i>S</i>)- and (<i>R</i>)-α-Methylproline-Derived Ligands for the Direct Chemical Resolution of Free Unprotected β³-Amino Acids
  作者：Shengbin Zhou、Shuni Wang、Jiang Wang、Yong Nian、Panfeng Peng、Vadim A. Soloshonok、Hong Liu

  DOI：10.1002/ejoc.201800120

  日期：2018.4.23

  A series of nonracemizable ligands are synthesized for the direct chemical resolution of various unprotected β3‐amino acids with high enantioselectivity and yields. One of the obtained free enantiomerically pure β‐amino acids can be applied directly as a starting material for the synthesis of the anti‐HIV drug maraviroc in an overall yield of 49 % in six steps.

  一系列nonracemizable配体被用于对各种未保护β的直接化学合成的分辨率3 -氨基酸高对映选择性和产率。获得的一种游离的对映体纯净的β-氨基酸可以直接用作合成抗HIV药物maraviroc的原料，分6步，总收率为49％。