3-氨基-4-苯基丁酸甲酯 | 129042-93-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-氨基-4-苯基丁酸甲酯
• 英文名称: methyl 3-amino-4-phenylbutanoate
• CAS: 129042-93-9
• 化学式: C₁₁H₁₅NO₂
• mdl: MFCD11616069
• 分子量: 193.246
• InChiKey: JFNXWNUTVYGPMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990

反应信息

• 作为反应物：
  描述：

  3-氨基-4-苯基丁酸甲酯 在 copper(ll) sulfate pentahydrate 、 1H-咪唑-1-磺酰叠氮盐酸盐 、 potassium carbonate 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以71%的产率得到methyl 3-azido-4-phenylbutanoate
  参考文献：
  名称：

  [EN] 5-MEMBERED HETEROARYL COMPOUNDS CONTAINING A HYDROXAMATE MOIETY AND THEIR USE
  [FR] COMPOSÉS HÉTÉROARYLES À 5 CHAÎNONS CONTENANT UNE FRACTION HYDROXAMATE ET LEUR UTILISATION

  摘要：

  本发明涉及含有Formula I的羟肟基团的5-成员杂芳化合物，其药用可接受盐或溶剂，以及它们作为恶性肿瘤化疗的增敏剂的用途。

  公开号：

  WO2020148403A1
• 作为产物：
  描述：

  methyl 3-amino-4-phenylbutanoate;4-methylbenzenesulfonic acid 在 氨 作用下， 以 乙醚 为溶剂， 生成 3-氨基-4-苯基丁酸甲酯
  参考文献：
  名称：

  Liou, Lara R.; McNeil, Anne J.; Toombes, Gilman E. S., Journal of the American Chemical Society, 2008, vol. 130, p. 17334 - 17341

  摘要：

  DOI：

文献信息

• SUBSTITUTED CARBAMOYLCYCLOALKYL ACETIC ACID DERIVATIVES AS NEP
  申请人：KARKI Rajeshri Ganesh

  公开号：US20120122764A1

  公开（公告）日：2012-05-17

  The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , B, X, m and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of compounds of the invention, and a combination of pharmacologically active agents and a compound of the invention.

  本发明提供了一种具有化学式I的化合物； 或其药学上可接受的盐，其中R 1 ，R 2 ，R 3 ，R 4 ，R 5 ，B，X，m和n在此处被定义。该发明还涉及制造该发明化合物的方法及其治疗用途。本发明进一步提供了该发明化合物的药物组合物，以及具有药理活性剂和该发明化合物的组合。
• Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer
  申请人：Hasumi Keiji

  公开号：US20090216028A1

  公开（公告）日：2009-08-27

  The present invention provides a triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), R 1 represents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen; R 4 in the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below; X represents —CHY—(CH 3 ) 2 Z; and Y and Z are respectively —H or —OH or together form a single bond: (III-1) wherein R 5 represents a hydroxyl group which may be present or absent; and n represents an integer of 0 or 1.

  本发明提供了一种由以下化学式（II）和（III）所代表的三倍萜酚化合物，具有增强溶栓活性，以及一种高效制备该三倍萜酚化合物的方法。在化学式（II）和（III）中，R1代表芳香基团，其作为取代基或取代基的一部分至少包括羧基、羟基、磺酸基和二级氨基组成的群中的一种，或者是包含二级氨基并可能包含氮的芳香基团；在通式（III）中，R4代表由通式（III-1）所表示的芳香氨基酸残基；X代表—CHY—（CH3）2Z；Y和Z分别为—H或—OH或形成单键：（III-1）其中，R5代表可能存在或不存在的羟基；n代表0或1的整数。
• TRIPRENYL PHENOL COMPOUND, PROCESS FOR PRODUCTION OF TRIPRENYL PHENOL COMPOUND, AND THROMBOLYSIS ENHANCER
  申请人：HASUMI Keiji

  公开号：US20120100579A1

  公开（公告）日：2012-04-26

  A triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), R 1 represents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen; R 4 in the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below; X represents —CHY—(CH 3 ) 2 Z; and Y and Z are respectively —H or —OH or together form a single bond: (III-1) wherein R 5 represents a hydroxyl group which may be present or absent; and n represents an integer of 0 or 1.

  以下为一种由式子（II）和（III）所代表的三倍半萜酚类化合物，具有促进溶血性的活性，以及一种高效的制备该三倍半萜酚类化合物的方法。在式子（II）和（III）中，R1代表一种芳香基团，其作为一个取代基或部分取代基，至少包含羧基、羟基、磺酸基和次级氨基中的一种，或者是包含次级氨基且可能包含氮的芳香基团；在一般式（III）中，R4代表由一般式（III-1）所表示的芳香氨基酸残基；X代表—CHY—（CH3）2Z；Y和Z分别代表—H或—OH，或者一起形成一个单键：（III-1）其中R5代表可能存在或不存在的羟基；n代表0或1的整数。
• Quinazolinedione Chymase Inhibitors
  申请人：Guo Xin

  公开号：US20120122863A1

  公开（公告）日：2012-05-17

  Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving Chymase.

  公开了小分子抑制剂，可用于治疗涉及Chymase的各种疾病和病况。
• TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2
  申请人：Minucci Saverio

  公开号：US20130035377A1

  公开（公告）日：2013-02-07

  Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R 3 are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to compositions containing them and to therapeutic use thereof.

  Tranylcypromine衍生物可用作治疗剂，特别是用于预防和/或治疗与组蛋白去甲基化酶LSD1和LSD2活性相关的疾病和病况，例如由基因转录、细胞分化和增殖失调所特征的疾病，如肿瘤、病毒感染等。这些化合物属于结构式（I），其中A和R3的定义如规范所述。本发明还涉及这些化合物的制备，以及含有它们的组合物和其治疗用途。