5-Ethoxy-2-methyl-1,3-thiazole-4-sulfonyl chloride | 89502-03-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Ethoxy-2-methyl-1,3-thiazole-4-sulfonyl chloride
• 英文别名: 5-ethoxy-2-methyl-1,3-thiazole-4-sulfonyl chloride
• CAS: 89502-03-4
• 化学式: C₆H₈ClNO₃S₂
• 分子量: 241.7
• InChiKey: LRUOTUHZPGOBAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  92.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20160304505A1

  公开（公告）日：2016-10-20

  The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R a , R b , R c , R d , R g , and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.
• CARBAMATE BENZOXAZINE PROPIONIC ACIDS AND ACID DERIVATIVES FOR MODULATION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20160311787A1

  公开（公告）日：2016-10-27

  The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof wherein R 1 , R 2 , R a1 , R a2 , R b1 , R b2 , R c , R d , and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.
• US9663502B2
  申请人：——

  公开号：US9663502B2

  公开（公告）日：2017-05-30
• US9783511B2
  申请人：——

  公开号：US9783511B2

  公开（公告）日：2017-10-10