3,6-dimethoxy-7β,17-dimethyl-4-phenoxy-5,6,8,14-tetrahydromorphinan | 75702-09-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 3,6-dimethoxy-7β,17-dimethyl-4-phenoxy-5,6,8,14-tetrahydromorphinan
• 英文别名: 3,6-Dimethoxy-7β,17-dimethyl-4-phenoxy-5,6,8,14-tetradehydromorphinane；3,6-Dimethoxy-7beta,17-dimethyl-4-phenoxy-5,6,8,14-tetradehydromorphinane；(1S,9R,12R)-4,13-dimethoxy-12,17-dimethyl-3-phenoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,10,13-pentaene
• CAS: 75702-09-9
• 化学式: C₂₆H₂₉NO₃
• 分子量: 403.521
• InChiKey: ONAVYJRQQSLOEC-GZAUMTHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,6-dimethoxy-7β,17-dimethyl-4-phenoxy-5,6,8,14-tetrahydromorphinan 在 palladium on activated charcoal 盐酸 、 氨 、 氢气 、 sodium 作用下， 以 乙醇 、 甲苯 为溶剂， -78.0~100.0 ℃ 、344.73 kPa 条件下， 反应 5.0h， 生成 7α,17-dimethyl-3-methoxymorphinan-6-one
  参考文献：
  名称：

  Analgesic narcotic antagonists. 4. 7-Methyl-N-(cycloalkylmethyl)-3-hydroxy morphinan-6-one and -isomorphinan-6-one

  摘要：

  3,6-Dimethoxy-7 beta, 17-dimethyl-4-hydroxy-5,6,8,14-tetradehydromorphinan (2) was converted to the 4-deoxy compound 4 and hydrolyzed to a mixture of the B/C-cis (C series) and B/C-trans (T series) isomers of 7,8-didehydromorphinan-6-one, 5. Hydrogenation of the separated isomers gave 7-methyl-6-oxo derivatives 6a. 7,8-Dimethyl-(6b) or 7-methyl-8-ethylmorphinan-6-one (6c) was prepared by reaction of 5 with lithium organocuprates. The analgesic N-methyl compounds 6 were converted to 17-(cyclopropylmethyl) or 17-(cyclobutylmethyl) derivatives 10--13. Some of these compounds had mixed profiles of narcotic agonist-antagonist effects. Studies with drug-dependent monkeys indicated that several of these compounds with an analgesic-antagonist ratio of less than 0.4 substitute for morphine.

  DOI：

  10.1021/jm00186a025
• 作为产物：
  描述：

  溴苯 、 3,6-dimethoxy-7β,17-dimethyl-4-hydroxy-5,6,8,14-tetradehydro-morphinane 在 吡啶 、 铜 、 potassium carbonate 作用下， 反应 48.0h， 以85%的产率得到3,6-dimethoxy-7β,17-dimethyl-4-phenoxy-5,6,8,14-tetrahydromorphinan
  参考文献：
  名称：

  Analgesic narcotic antagonists. 4. 7-Methyl-N-(cycloalkylmethyl)-3-hydroxy morphinan-6-one and -isomorphinan-6-one

  摘要：

  3,6-Dimethoxy-7 beta, 17-dimethyl-4-hydroxy-5,6,8,14-tetradehydromorphinan (2) was converted to the 4-deoxy compound 4 and hydrolyzed to a mixture of the B/C-cis (C series) and B/C-trans (T series) isomers of 7,8-didehydromorphinan-6-one, 5. Hydrogenation of the separated isomers gave 7-methyl-6-oxo derivatives 6a. 7,8-Dimethyl-(6b) or 7-methyl-8-ethylmorphinan-6-one (6c) was prepared by reaction of 5 with lithium organocuprates. The analgesic N-methyl compounds 6 were converted to 17-(cyclopropylmethyl) or 17-(cyclobutylmethyl) derivatives 10--13. Some of these compounds had mixed profiles of narcotic agonist-antagonist effects. Studies with drug-dependent monkeys indicated that several of these compounds with an analgesic-antagonist ratio of less than 0.4 substitute for morphine.

  DOI：

  10.1021/jm00186a025

文献信息

• 7-Methyl-8.beta.-lower alkyl or 7-methyl-8-lower alkyl B/C cis or trans
  申请人：Miles Laboratories, Inc.

  公开号：US04230712A1

  公开（公告）日：1980-10-28

  Disclosed are 7-methyl, 8.beta.-lower alkyl and 7 methyl-8-lower alkyl substituted B/C Cis or Trans morphinan-6-one compounds characterized by the structural formula: ##STR1## Specific compounds, included within the scope of the foregoing general formula wherein R.sub.1 is H or methyl, R.sub.2 is cyclopropylmethyl or cyclobutylmethyl, R.sub.3 is H, methyl, ethyl or n-propyl and R.sub.4 is H or methyl are useful as mixed analgesics/narcotic antagonists.

  揭示了具有以下结构式的7-甲基，8.beta.-较低烷基和7-甲基-8-较低烷基取代的B/C顺式或反式吗啡酮化合物：具体化合物包括在上述一般式范围内，其中R.sub.1为H或甲基，R.sub.2为环丙基甲基或环丁基甲基，R.sub.3为H，甲基，乙基或正丙基，R.sub.4为H或甲基，可用作混合镇痛剂/麻醉拮抗剂。
• 7-Methyl and 7-methyl-8-lower alkyl B/C cis or trans morphinan-6-one compounds, process for their preparation and pharmaceutical preparations containing them
  申请人：MILES LABORATORIES, INC.

  公开号：EP0019254B1

  公开（公告）日：1982-09-01
• US4230712A
  申请人：——

  公开号：US4230712A

  公开（公告）日：1980-10-28
• Analgesic narcotic antagonists. 4. 7-Methyl-N-(cycloalkylmethyl)-3-hydroxy morphinan-6-one and -isomorphinan-6-one
  作者：David L. Leland、Michael P. Kotick

  DOI：10.1021/jm00186a025

  日期：1980.12

  3,6-Dimethoxy-7 beta, 17-dimethyl-4-hydroxy-5,6,8,14-tetradehydromorphinan (2) was converted to the 4-deoxy compound 4 and hydrolyzed to a mixture of the B/C-cis (C series) and B/C-trans (T series) isomers of 7,8-didehydromorphinan-6-one, 5. Hydrogenation of the separated isomers gave 7-methyl-6-oxo derivatives 6a. 7,8-Dimethyl-(6b) or 7-methyl-8-ethylmorphinan-6-one (6c) was prepared by reaction of 5 with lithium organocuprates. The analgesic N-methyl compounds 6 were converted to 17-(cyclopropylmethyl) or 17-(cyclobutylmethyl) derivatives 10--13. Some of these compounds had mixed profiles of narcotic agonist-antagonist effects. Studies with drug-dependent monkeys indicated that several of these compounds with an analgesic-antagonist ratio of less than 0.4 substitute for morphine.