1-(Pyridin-4-ylmethyl)-1H-imidazole-5-carboxylic acid | 1707575-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(Pyridin-4-ylmethyl)-1H-imidazole-5-carboxylic acid
• 英文别名: 3-(pyridin-4-ylmethyl)imidazole-4-carboxylic acid
• CAS: 1707575-92-5
• 化学式: C₁₀H₉N₃O₂
• 分子量: 203.2
• InChiKey: WLWGEDUFVNVEOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  68
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 1-(AROMATIC- OR HETEROAROMATIC-SUBSTITUTED)-3-(HETEROAROMATIC SUBSTITUTED)-1,3-PROPANEDIONES AND USES THEREOF
  申请人：Merck & Co., Inc.

  公开号：EP1196384A1

  公开（公告）日：2002-04-17
• EP1196384A4
  申请人：——

  公开号：EP1196384A4

  公开（公告）日：2002-10-23
• [EN] 1-(AROMATIC- OR HETEROAROMATIC-SUBSTITUTED)-3-(HETEROAROMATIC SUBSTITUTED)-1,3-PROPANEDIONES AND USES THEREOF<br/>[FR] 1,3-PROPANEDIONES-1-(AROMATIQUES OU HETEROAROMATIQUES SUBSTITUTEES)-3-(HETEROAROMATIQUES SUBSTITUEES) ET LEUR UTILISATION
  申请人：MERCK & CO INC

  公开号：WO2001000578A1

  公开（公告）日：2001-01-04

  Certain 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.