methyl 3-[1-(4-methylbenzyl)-1H-imidazol-5-yl]propanoate | 1185760-45-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: methyl 3-[1-(4-methylbenzyl)-1H-imidazol-5-yl]propanoate
• 英文别名: Methyl 3-[3-[(4-methylphenyl)methyl]imidazol-4-yl]propanoate
• CAS: 1185760-45-5
• 化学式: C₁₅H₁₈N₂O₂
• 分子量: 258.32
• InChiKey: JWXUKTBFRJNZBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors
  申请人：Maastricht University

  公开号：EP2095819A1

  公开（公告）日：2009-09-02

  The invention relates to the use of a N-benzyl 5-substituted imidazole derivative having the general formula I wherein R is (C1-3)alkyl, (C1-3)alkyloxy, halogen, nitro or cyano; R1 is (C1-6)alkyl, optionally substituted with OH, (C1-3)alkyloxy, (C1-3)alkylcarbonyloxy, (C1-3)alkyloxycarbonyl or halogen, or (C1-3)alkyloxycarbonyl; or R1 is phenyl, optionally substituted with 1-3 substituents independently selected from (C1-3)alkyl, (C1-3)alkyloxy, hydroxylmethyl and halogen; or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment of a disorder or disease in a subject mediated by aldosterone synthase or responsive to inhibition of aldosterone synthase.

  该发明涉及使用具有通式I的N-苄基5-取代咪唑衍生物，其中R为(C1-3)烷基，(C1-3)烷氧基，卤素，硝基或氰基；R1为(C1-6)烷基，可选择地取代为羟基，(C1-3)烷氧基，(C1-3)烷基羰氧基，(C1-3)烷氧羰基或卤素，或(C1-3)烷氧羰基；或R1为苯基，可选择地取代为1-3个独立选择自(C1-3)烷基，(C1-3)烷氧基，羟甲基和卤素的取代基；或其药学上可接受的盐，用于制备一种药物，用于治疗由醛固酮合酶介导或对醛固酮合酶抑制响应的受体引起的主体的紊乱或疾病。
• [EN] N-BENZYL IMIDAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS DE N-BENZYL-IMIDAZOLE
  申请人：MAASTRICHT UNIVERSITY

  公开号：WO2009106640A2

  公开（公告）日：2009-09-03

  The invention relates to the use of a N-benzyl 5-substituted imidazole derivative having the general formula (I) wherein R is (C1-3)alkyl, (C1-3)alkyloxy, halogen, nitro or cyano; R1 is formyl, (C1-6)alkyl, optionally substituted with OH, (C1-3)alkyloxy, (C1-3)alkylcarbonyloxy, (C1-3)alkyloxy- carbonyl or halogen, or (C1-3)alkyloxycarbonyl; or R1 is phenyl, optionally substituted with 1 -3 substituents independently selected from (C1-3)alkyl, (C1-3)alkyloxy, hydroxylmethyl and halogen; or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment of a disorder or disease in a subject mediated by aldosterone synthase or responsive to inhibition of aldosterone synthase.