7-methoxy-8-{3-[(5-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-2-methoxyphenyl)oxy]propyloxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one | 1251485-19-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 7-methoxy-8-{3-[(5-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-2-methoxyphenyl)oxy]propyloxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
• 英文别名: (6aS)-3-[3-[5-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-2-methoxyphenoxy]propoxy]-2-methoxy-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-11-one
• CAS: 1251485-19-4
• 化学式: C₃₁H₂₉FN₄O₆
• 分子量: 572.593
• InChiKey: MXHKMODFZWREML-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  42
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  109
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  在 calcium carbonate 、 mercury dichloride 作用下， 以 水 、 乙腈 为溶剂， 反应 12.0h， 以332 mg的产率得到7-methoxy-8-{3-[(5-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-2-methoxyphenyl)oxy]propyloxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
  参考文献：
  名称：

  Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5-diaryloxadiazole–pyrrolobenzodiazepine conjugates

  摘要：

  A series of 2,5-diaryloxadiazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates have been prepared and evaluated for their anticancer activity. These conjugates have shown promising activity with GI(50) values ranging from < 0.1 to 0.29 mu M. It is observed that some of these conjugates particularly 4a, 4d, 4i and 4l exhibit significant anticancer activity. Some detailed biological assays relating to the cell cycle aspects associated to Bax and caspases have been examined with a view to understand the mechanism of action of these conjugates. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.07.067

文献信息

• Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5-diaryloxadiazole–pyrrolobenzodiazepine conjugates
  作者：Ahmed Kamal、D. Dastagiri、M. Janaki Ramaiah、E. Vijaya Bharathi、J. Surendranadha Reddy、G. Balakishan、Pranjal Sarma、S.N.C.V.L. Pushpavalli、Manika Pal-Bhadra、Aarti Juvekar、Subrata Sen、Surekha Zingde

  DOI：10.1016/j.bmc.2010.07.067

  日期：2010.9

  A series of 2,5-diaryloxadiazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates have been prepared and evaluated for their anticancer activity. These conjugates have shown promising activity with GI(50) values ranging from < 0.1 to 0.29 mu M. It is observed that some of these conjugates particularly 4a, 4d, 4i and 4l exhibit significant anticancer activity. Some detailed biological assays relating to the cell cycle aspects associated to Bax and caspases have been examined with a view to understand the mechanism of action of these conjugates. (c) 2010 Elsevier Ltd. All rights reserved.