N,N-Dioctadecyl-14-amino-5-oxo-3,9,12-trioxa-6-azatetradecansaeureamid | 154269-31-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-Dioctadecyl-14-amino-5-oxo-3,9,12-trioxa-6-azatetradecansaeureamid
• CAS: 154269-31-5
• 化学式: C₄₆H₉₃N₃O₅
• 分子量: 768.262
• InChiKey: TYFUZUDAABXKCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.46
• 重原子数：
  54.0
• 可旋转键数：
  46.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  103.12
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  N,N-Dioctadecyl-14-amino-5-oxo-3,9,12-trioxa-6-azatetradecansaeureamid 、 fluorescein isothiocyanate 以 氯仿 、 二甲基亚砜 为溶剂， 反应 8.0h， 以70%的产率得到5-[3-(2-{2-[2-(2-Dioctadecylcarbamoylmethoxy-acetylamino)-ethoxy]-ethoxy}-ethyl)-thioureido]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid
  参考文献：
  名称：

  Investigation of Specific Binding of Antifluorescyl Antibody and Fab to Fluorescein Lipids in Langmuir-Blodgett Deposited Films Using Quartz Crystal Microbalance Methodology

  摘要：

  Antifluorescyl IgG antibody and Fab binding to two fluorescein-conjugated lipids was measured using the quartz crystal microbalance methodology. By use of the Langmuir-Blodgett technique, the fluorescein lipids, which were diluted to 5% in a L-alpha-dipalmitoyl phosphatidylethanolamine (DPPE) matrix, were deposited directly onto one gold electrode of the quartz crystal. Binding to films containing the fluorescein hapten was significantly enhanced compared to films of the pure DPPE matrix lipid, indicating that binding occurred primarily through a specific interaction. Association constants were 40-300 times less than for binding to haptens free in solution. Binding of IgG to the lipid in which the hydrocarbon chains and the fluorescein hapten were linked via a hydrophilic spacer was similar to 7 times as great as to the lipid containing no spacer. IgG binding to the lipid containing the spacer was increased 1.5-4.4 times compared to Fab binding for the same lipid. Equilibrium binding curves and kinetic measurements are analyzed quantitatively and compared.

  DOI：

  10.1021/ac00082a014
• 作为产物：
  描述：

  1,8-二氨基-3,6-二氧杂辛烷 、 dioctadecylcarbamoylmethoxyacetic acid 在 N,N'-羰基二咪唑 作用下， 生成 N,N-Dioctadecyl-14-amino-5-oxo-3,9,12-trioxa-6-azatetradecansaeureamid
  参考文献：
  名称：

  Ebato, Hiroshi; Herron, James N.; Mueller, Wolfgang, Angewandte Chemie, 1992, vol. 104, # 8, p. 1064 - 1066

  摘要：

  DOI：