Prop-2-ynyl 2-butylsulfanylcarbothioylsulfanyl-2-methylpropanoate | 1401416-31-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Prop-2-ynyl 2-butylsulfanylcarbothioylsulfanyl-2-methylpropanoate
• CAS: 1401416-31-6
• 化学式: C₁₂H₁₈O₂S₃
• 分子量: 290.472
• InChiKey: CDKWJHJHXWPUQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.49
• 重原子数：
  17.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  2-(((butylthio)carbonothioyl)thio)-2-methylpropanoic acid 、 2-丙炔-1-醇 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.5h， 生成 Prop-2-ynyl 2-butylsulfanylcarbothioylsulfanyl-2-methylpropanoate
  参考文献：
  名称：

  GRGD装饰的三维纳米蠕虫水凝胶，用于培养人类胚胎干细胞

  摘要：

  人类胚胎干细胞（hESCs）为再生医学的发展带来了巨大希望。本文演示了一种制备温度诱导的三维（3D）水凝胶的方法，该水凝胶由半径为10 nm的微米级长度的柔软和柔性聚合物纳米蠕虫组成。我们使用新的物理吸附方法用整联蛋白结合肽（RGD）装饰了纳米蠕虫的表面，并表明所得的凝胶能够固定并维持hESC的存活。我们得出的结论是，独特的PNIPAM纳米蠕虫水凝胶允许未分化的hESC通过小的整合素结合肽结合。它们的温度敏感性，生物相容性，能够将多种配体和可模压性组合呈现为任何所需的3D形状的能力，将使该纳米蠕虫系统成为将来用于类器官工程和再生医学的多功能平台。分级为4 +©2019 Wiley Periodicals，Inc.J.Polym。科学，A部分：Polym。化学 2019，57，1956–1963

  DOI：

  10.1002/pola.29342

文献信息

• Temperature-Directed Self-Assembly of Multifunctional Polymeric Tadpoles
  作者：Valentin A. Bobrin、Michael J. Monteiro

  DOI：10.1021/jacs.5b11037

  日期：2015.12.23

  Multicompartment tadpole nano-objects are a rare and intriguing class of structures with potential in a wide range of applications. Here, we demonstrate the synthesis of chemically multifunctional polymer tadpoles made at high weight fractions of polymer (>10 wt %). The tadpoles are synthesized using two different thermoresponsive MacroCTAs with either alkyne or pyridyldisulfide end-groups, allowing chemical functionality in the head, tail, or both. Water-soluble molecules or polymers were coupled to either the head, tail or both without a change in tadpole configuration. In addition, the tadpoles can be dried, rehydrated, and stored in water for 5 months without a change in shape. This method represents a new and an important synthetic development in the design of nano-objects.
• Multifunctional Nanoworms and Nanorods through a One-Step Aqueous Dispersion Polymerization
  作者：Zhongfan Jia、Valentin A. Bobrin、Nghia P. Truong、Marianne Gillard、Michael J. Monteiro

  DOI：10.1021/ja500092m

  日期：2014.4.23

  Producing synthetic soft worm and rod structures with multiple chemical functionalities on the surface would provide potential utility in drug delivery, nanoreactors, tissue engineering, diagnostics, rheology modifiers, enzyme mimics, and many other applications. Here, we have synthesized multifunctional worms and rods directly in water using a one-step reversible addition-fragmentation chain transfer (RAFT)-mediated dispersion polymerization at high weight fractions of polymer (>10 wt %). The chain-end functionalities included alkyne, pyridyl disulfide, dopamine, beta-thiolactone, and biotin groups. These groups could further be converted or coupled with biomolecules or polymers. We further demonstrated a nanorod colorimetric system with good control over the attachment of fluorescent probes.
• ANTIMICROBIAL NANOWORMS
  申请人：THE BOEING COMPANY

  公开号：US20220331262A1

  公开（公告）日：2022-10-20

  At least one nanoworm comprises a plurality of alkene units and a plurality of macroCTA polymer units. The macroCTA polymer units include R 1 groups from reversible addition-fragmentation chain-transfer agents. In certain aspects, the R 1 groups of the macroCTA polymer units are functional groups, such as a carboxylic acid, an alkyne, a pyridine, a dopamine, a thiolactone, a biotin, an azide, a peptide sequence, a sugar sequence, a protease, a glycanase, a polymer, other functional groups, and combinations thereof. In certain aspects, the macroCTA polymer units comprise quaternized amines, In certain aspects, the macroCTA polymer units comprise functionalized quaternized amines, such as an alkyl group, a carboxylic acid, an alkyne, a pyridine, a dopamine, a thiolactone, a biotin, an azide, a peptide sequence, a sugar sequence, a protease, a glycanase, a polymer, other functional groups, and combinations thereof. In certain aspects, the coating comprises the at least one nanoworm.