5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-5-yl]-2-[5-(pentan-3-yl)-1,2,4-oxadiazol-3-yl]pyridine | 1254167-90-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-5-yl]-2-[5-(pentan-3-yl)-1,2,4-oxadiazol-3-yl]pyridine
• 英文别名: 3-[5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-5-yl]pyridin-2-yl]-5-pentan-3-yl-1,2,4-oxadiazole
• CAS: 1254167-90-2
• 化学式: C₂₁H₁₉ClFN₅O
• 分子量: 411.866
• InChiKey: ZHTIJTGYEUMVGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  80.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS<br/>[FR] COMPOSÉS ET COMPOSITIONS COMME INHIBITEURS DE LA PROSTAGLANDINE E SYNTHASE-1 MICROSOMALE
  申请人：IRM LLC

  公开号：WO2010127152A2

  公开（公告）日：2010-11-04

  Provided herein are compounds, and pharmaceutical compositions comprising such compounds, wherein the compounds are inhibitors of mPGES-1 activity. Also provided herein are methods of using such compounds and composition to treat or prevent diseases or disorders associated with the activity of mPGES-1.