4-(3-Cyclohexyl-5-phenyl-1H-pyrazol-1-yl)-2-(hydroxymethyl)benzenesulfonamide | 304648-30-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(3-Cyclohexyl-5-phenyl-1H-pyrazol-1-yl)-2-(hydroxymethyl)benzenesulfonamide
• 英文别名: 4-(3-cyclohexyl-5-phenylpyrazol-1-yl)-2-(hydroxymethyl)benzenesulfonamide
• CAS: 304648-30-4
• 化学式: C₂₂H₂₅N₃O₃S
• 分子量: 411.525
• InChiKey: UHXJVDWRJJEVKG-UHFFFAOYSA-N

物化性质

• 沸点：
  665.2±65.0 °C(predicted)
• 密度：
  1.36±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-cyclohexyl-3-phenylpropane-1,3-dione 、 4-hydrazino-2-hydroxymethyl-1-benzenesulfonamide 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 72.0h， 以16%的产率得到4-(3-Cyclohexyl-5-phenyl-1H-pyrazol-1-yl)-2-(hydroxymethyl)benzenesulfonamide
  参考文献：
  名称：

  CYCLOHEXANE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

  摘要：

  公开号：

  EP2341047B1

文献信息

• [EN] PYRAZOLES HAVING ANTIINFLAMMATORY ACTIVITY<br/>[FR] PYRAZOLES PRESENTANT UNE ACTIVITE ANTI-INFLAMMATOIRE
  申请人：REDDY RESEARCH FOUNDATION

  公开号：WO2000066562A1

  公开（公告）日：2000-11-09

  The present invention relates to novel antiinflammatory compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their regioisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel heterocyclic compounds of general the formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their regioisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

  本发明涉及新型抗炎化合物、它们的衍生物、类似物、互变异构体、立体异构体、区域异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化合物以及含有它们的药学上可接受的组合物。更具体地说，本发明涉及一般式（I）的新型杂环化合物、它们的衍生物、类似物、互变异构体、立体异构体、区域异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化合物以及含有它们的药学上可接受的组合物。
• Cyclohexane derivative and pharmaceutical use thereof
  申请人：Toray Industries, Inc.

  公开号：US08247569B2

  公开（公告）日：2012-08-21

  A compound has a strong analgesic action against both nociceptive pain and neuropathic pain and has less side effects, and is medically useful. The compound includes cyclohexane derivatives represented by the following compound, or pharmaceutically acceptable salts thereof or prodrugs thereof.

  这个化合物对于伤害性疼痛和神经病理性疼痛都有强烈的止痛作用，副作用较少，因此在医学上具有实用价值。该化合物包括以下化合物所代表的环己烷衍生物，或其药学上可接受的盐或前药。
• THERAPEUTIC AGENT AND PREVENTATIVE AGENT FOR ALZHEIMER'S DISEASE
  申请人：Toray Industries, Inc.

  公开号：EP2565184A1

  公开（公告）日：2013-03-06

  An object of the present invention is to provide a therapeutic agent or prophylactic agent for Alzheimer's disease, which has an effect to inhibit or delay the progress of Alzheimer's disease and exhibits a long-lasting therapeutic effect on Alzheimer's disease even when used for a long period of time. The present invention provides a therapeutic agent or prophylactic agent for Alzheimer's disease, said agent comprising as an effective ingredient a cyclohexane derivative exemplified by the formula below, or a pharmaceutically acceptable salt thereof or a prodrug thereof.

  本发明的目的是提供一种阿尔茨海默病的治疗剂或预防剂，该治疗剂或预防剂具有抑制或延缓阿尔茨海默病进展的作用，即使长期使用也能对阿尔茨海默病产生持久的治疗效果。本发明提供了一种阿尔茨海默病的治疗剂或预防剂，所述治疗剂作为有效成分包括如下式所示的环己烷衍生物，或其药学上可接受的盐或其原药。
• THERAPEUTIC AGENT OR PREVENTIVE AGENT FOR URINE COLLECTION DISORDER
  申请人：Hareyama Nana

  公开号：US20130041157A1

  公开（公告）日：2013-02-14

  A therapeutic agent or prophylactic agent is effective for therapy of urine storage disorders, by which agent improvement of side effects due to an anticholinergic action is attained as well as which agent also has an analgesic effect. The agent includes as an effective ingredient a cyclohexane derivative exemplified by the formula below, a pharmaceutically acceptable salt thereof, or a prodrug thereof.
• THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR FIBROMYALGIA
  申请人：Yoshida Chihiro

  公开号：US20130190503A1

  公开（公告）日：2013-07-25

  A therapeutic agent or prophylactic agent has an analgesic effect on both nociceptive pain and neuropathic pain and is effective in treatment of fibromyalgia. The agent includes as an effective ingredient a cyclohexane derivative or a pharmaceutically acceptable salt thereof or a prodrug thereof.