1-(1,3-bis((1,3-dihydroxypropan-2-yl)oxy)propan-2-yl) 2,5-dioxopyrrolidin-1-yl succinate | 1382190-20-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1-(1,3-bis((1,3-dihydroxypropan-2-yl)oxy)propan-2-yl) 2,5-dioxopyrrolidin-1-yl succinate
• CAS: 1382190-20-6
• 化学式: C₁₇H₂₇NO₁₂
• 分子量: 437.401
• InChiKey: NNQWNNAZXGRCEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.97
• 重原子数：
  30.0
• 可旋转键数：
  15.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  189.36
• 氢给体数：
  4.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  1-(1,3-bis((1,3-dihydroxypropan-2-yl)oxy)propan-2-yl) 2,5-dioxopyrrolidin-1-yl succinate 、 3'-N-debenzoylpaclitaxel 在 1-羟基苯并三唑 、 N,N-二甲基苯胺 作用下， 以 四氢呋喃 为溶剂， 反应 19.0h， 以73%的产率得到(1S,2S,4S,9S,10S,15S,3R,7R,12R)-4,12-diacetyloxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-2-phenylcarbonyloxy-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-15-yl (3S,2R)-2-hydroxy-3-{3-[(2-[2-hydroxy-1-(hydroxymethyl)ethoxy]-1-{[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl}ethyl)oxycarbonyl]propanoylamino}-3-phenylpropanoate
  参考文献：
  名称：

  Synthesis of Paclitaxel–BGL Conjugates

  摘要：

  Four kinds of symmetrically branched oligoglyceryl trimeric (BGL003)-paclitaxel conjugates and a corresponding heptameric (BGL007) conjugate were synthesized. Molecular weights of all the compounds were less than two times that of paclitaxel. The anti-tumor activity of the most water-soluble BGL003 conjugate was examined and found to be preserved in spite of the chemical modification that is displacement of the N3'-debenzoyl residue with the BGL003 succinyl residue. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.07.031
• 作为产物：
  描述：

  1-(1,3-bis((2-phenyl-1,3-dioxan-5-yl)oxy)propan-2-yl) 2,5-dioxopyrrolidin-1-yl succinate 在 氢气 、 palladium(II) hydroxide 作用下， 以 乙醇 为溶剂， 反应 15.0h， 生成 1-(1,3-bis((1,3-dihydroxypropan-2-yl)oxy)propan-2-yl) 2,5-dioxopyrrolidin-1-yl succinate
  参考文献：
  名称：

  Synthesis of Paclitaxel–BGL Conjugates

  摘要：

  Four kinds of symmetrically branched oligoglyceryl trimeric (BGL003)-paclitaxel conjugates and a corresponding heptameric (BGL007) conjugate were synthesized. Molecular weights of all the compounds were less than two times that of paclitaxel. The anti-tumor activity of the most water-soluble BGL003 conjugate was examined and found to be preserved in spite of the chemical modification that is displacement of the N3'-debenzoyl residue with the BGL003 succinyl residue. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.07.031