4-hydroxyspiro[1H-indole-3,1'-cyclopentane]-2-one | 424792-54-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-hydroxyspiro[1H-indole-3,1'-cyclopentane]-2-one
• CAS: 424792-54-1
• 化学式: C₁₂H₁₃NO₂
• 分子量: 203.241
• InChiKey: QQKPNBWQMOUOQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-hydroxyspiro[1H-indole-3,1'-cyclopentane]-2-one 、 (S)-(+)- 间硝基苯磺酸缩水甘油酯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 18.0h， 生成
  参考文献：
  名称：

  Potent oxindole based human β3 adrenergic receptor agonists

  摘要：

  The synthesis and biological evaluation of a series of oxindole beta(3) adrenergic receptor agonists is described. A modulation of rat atrial tachycardia was observed with substitution at the 3-position of the oxindole moiety. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.011
• 作为产物：
  描述：

  4-methoxy-2-oxoindoline-3-spirocyclopentane 在 吡啶盐酸盐 作用下， 生成 4-hydroxyspiro[1H-indole-3,1'-cyclopentane]-2-one
  参考文献：
  名称：

  Potent oxindole based human β3 adrenergic receptor agonists

  摘要：

  The synthesis and biological evaluation of a series of oxindole beta(3) adrenergic receptor agonists is described. A modulation of rat atrial tachycardia was observed with substitution at the 3-position of the oxindole moiety. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.011

文献信息

• Potent oxindole based human β3 adrenergic receptor agonists
  作者：F. Craig Stevens、William E. Bloomquist、Anthony G. Borel、Marlene L. Cohen、Christine A. Droste、Mark L. Heiman、Aidas Kriauciunas、Daniel J. Sall、Frank C. Tinsley、Cynthia D. Jesudason

  DOI：10.1016/j.bmcl.2007.09.011

  日期：2007.11

  The synthesis and biological evaluation of a series of oxindole beta(3) adrenergic receptor agonists is described. A modulation of rat atrial tachycardia was observed with substitution at the 3-position of the oxindole moiety. (C) 2007 Elsevier Ltd. All rights reserved.