TREATING DIABETES WITH DIPEPTIDYL PEPTIDASE-IV INHIBITORS
申请人:Merck Sharp & Dohme Corp.
公开号:US20150175609A1
公开(公告)日:2015-06-25
The present invention is directed to novel substituted dihydropyrrolopyrazoles of structural Formula I which are inhibitors of the dipeptidyl peptidase-N enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase IV enzyme is involved.
US9156848B2
申请人:——
公开号:US9156848B2
公开(公告)日:2015-10-13
[EN] TREATING DIABETES WITH DIPEPTIDYL PEPTIDASE-IV INHIBITORS<br/>[FR] TRAITEMENT DU DIABÈTE PAR ADMINISTRATION D'INHIBITEURS DE DIPEPTIDYL PEPTIDASE-IV
申请人:MERCK SHARP & DOHME
公开号:WO2014018355A1
公开(公告)日:2014-01-30
The present invention is directed to novel substituted dihydropyrrolopyrazoles of structural Formula I which are inhibitors of the dipeptidyl peptidase-N enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase IV enzyme is involved.