Boc-Gly-Pro-Gly-Pro-Gly-Pro-OBzl | 55301-10-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Gly-Pro-Gly-Pro-Gly-Pro-OBzl
• CAS: 55301-10-5
• 化学式: C₃₃H₄₆N₆O₉
• 分子量: 670.763
• InChiKey: XHXJRBRWWIZIOH-SDHOMARFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.46
• 重原子数：
  48.0
• 可旋转键数：
  11.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  183.76
• 氢给体数：
  3.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  Boc-Gly-Pro-Gly-Pro-Gly-Pro-OBzl 在 氢气 、 钯 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 Boc-Gly-Pro-Gly-Pro-Gly-Pro-OH
  参考文献：
  名称：

  Structural-functional study of glycine-and-proline-containing peptides (Glyprolines) as potential neuroprotectors

  摘要：

  A synthetic scheme for preparation of (Gly-Pro) (n) , (Pro-Gly) (n) (n = 2, 3), and (Pro-Gly-Pro) (n) (n = 1, 2) peptides was elaborated. The effect of the synthesized peptides and the Gly-Pro and Pro-Gly dipeptides on survival of cultured cells of PC12 rat pheochromocytoma was studied under the conditions of oxidative stress induced by brief incubation of the cells with hydrogen peroxide. Peptides of the general formula (Gly-Pro) (n) and the Pro-Gly-Pro peptide at a concentration of 0.2-100 mu M were shown to decrease the number of damaged cells. The Gly-Pro peptide was the most active and decreased the number of damaged cells by 49% on average at a concentration of 100 mu M.

  DOI：

  10.1134/s1068162009020022

文献信息

• Amino acid and peptide derivatives of the tylosin family of macrolide antibiotics modified by aldehyde function
  作者：N. V. Sumbatyan、I. V. Kuznetsova、V. V. Karpenko、N. V. Fedorova、V. A. Chertkov、G. A. Korshunova、A. A. Bogdanov

  DOI：10.1134/s1068162010020159

  日期：2010.3

  Fourteen new functionally active amino acid and peptide derivatives of the antibiotics tylosin, desmycosin, and 5-O-mycaminosyltylonolide were synthesized in order to study the interaction of the growing polypeptide chain with the ribosomal tunnel. The conjugation of various amino acids and peptides with a macrolide aldehyde group was carried out by two methods: direct reductive amination with the isolation of the intermediate Schiff bases or through binding via oxime using the preliminarily obtained derivatives of 2-aminooxy-acetic acid.