3-Amino-1-(2,4-dichlorphenyl)-pyrazol | 90273-59-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-Amino-1-(2,4-dichlorphenyl)-pyrazol
• 英文别名: 1-(2,4-dichloro-phenyl)-1H-pyrazol-3-ylamine；1-(2,4-dichlorophenyl)-1H-pyrazol-3-amine；1-(2,4-dichlorophenyl)pyrazol-3-amine
• CAS: 90273-59-9
• 化学式: C₉H₇Cl₂N₃
• mdl: MFCD16845369
• 分子量: 228.081
• InChiKey: JMZWCUDIHPEHTE-UHFFFAOYSA-N

物化性质

• 熔点：
  119-120 °C(Solv: ligroine (8032-32-4))
• 沸点：
  381.6±37.0 °C(Predicted)
• 密度：
  1.50±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• HETEROARYL SUBSTITUTED PIPERIDINES
  申请人：Baumann Karlheinz

  公开号：US20110201605A1

  公开（公告）日：2011-08-18

  The invention relates to compounds of formula where hetaryl I, hetaryl II, R 1 , R 2 , R 3 , R 4 , m, n, and o are as defined in the specification or to pharmaceutically active acid addition salts thereof. The compounds of formula I are modulators for amyloid beta and thus may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

  该发明涉及以下式的化合物 其中hetaryl I，hetaryl II， R 1 ， R 2 ， R 3 ，R 4 ，m，n和o如规范中所定义 或其药用活性酸盐。式I的化合物是淀粉样蛋白β的调节剂，因此可能对与大脑中β-淀粉样蛋白沉积相关的疾病的治疗或预防有用，特别是阿尔茨海默病，以及其他疾病，如脑淀粉样血管病，遗传性脑出血伴淀粉样变性，荷兰型（HCHWA-D），多梗塞性痴呆，拳击性痴呆和唐氏综合征。
• HETEROCYCLIC COMPOUNDS AS PESTICIDES
  申请人：BAYER CROPSCIENCE AG

  公开号：US20150239847A1

  公开（公告）日：2015-08-27

  The present application relates to the use of heterocyclic compounds for controlling animal pests including arthropods, insects and nematodes, to novel heterocyclic compounds, to processes for their preparation and to intermediates for preparing the heterocyclic compounds.

  本申请涉及使用杂环化合物来控制动物害虫，包括节肢动物、昆虫和线虫，涉及新型杂环化合物，它们的制备方法以及制备杂环化合物的中间体。
• Yellow monoazo dyes of the 2-hydroxydibenzofuran series; their preparation and use for dyeing and printing synthetic hydrophobic fibres
  申请人：Montedison S.p.A.

  公开号：EP0011295A1

  公开（公告）日：1980-05-28

  Water-insoluble yellow monoazo dyes, having the formula: wherein R, and R2 are indifferently hydrogen atoms, alkyls having up to 4 carbon atoms, phenyls, also substituted; X is an atom selected from among hydrogen, chlorine and bromine, or it is an alkyl group, an alkoxyl group, a carboxyester group having up to 4 carbon atoms, a carboxyl group, a group CF3, CN, NO2, SO2CH3, a sulphonamido group, and n is an integer selected from among 1, and 3, methods of preparation and use of the foregoing are also disclosed. The above dyes are particularly suited for the dyeing and printing of hydrophobic synthetic fibers, in particular polyester fibers, with yellow shades.

  水不溶性黄色单偶氮染料，其化学式为 其中R和R2是不同的氢原子、最多有4个碳原子的烷基、苯基，也是取代的；X是从氢、氯和溴中选取的原子，或者是烷基、烷氧基、最多有4个碳原子的羧基、羧基、CF3、CN、NO2、SO2CH3基团、磺酰胺基团，n是从1和3中选取的整数，还公开了上述染料的制备和使用方法。 上述染料特别适用于疏水性合成纤维，尤其是涤纶纤维的黄色色调的染色和印花。
• Heterocyclic compounds as pesticides
  申请人：BAYER CROPSCIENCE AG

  公开号：US10435374B2

  公开（公告）日：2019-10-08

  The present application relates to the use of heterocyclic compounds for controlling animal pests including arthropods, insects and nematodes, to novel heterocyclic compounds, to processes for their preparation and to intermediates for preparing the heterocyclic compounds.

  本申请涉及使用杂环化合物防治动物害虫（包括节肢动物、昆虫和线虫）、新型杂环化合物、其制备工艺以及制备杂环化合物的中间体。
• HETEROCYCLISCHE VERBINDUNGEN ALS SCHÄDLINGSBEKÄMPFUNGSMITTEL
  申请人：Bayer CropScience AG

  公开号：EP2903440B1

  公开（公告）日：2017-09-06