methyl (2R,3S)-3-hydroxy-3-[3-[(3-hydroxy-2,2-dimethyl-3-phenylpropanoyl)amino]prop-1-ynyl]-2-(hydroxymethyl)-4,4-dimethyl-5-oxopyrrolidine-2-carboxylate | 1221973-73-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2R,3S)-3-hydroxy-3-[3-[(3-hydroxy-2,2-dimethyl-3-phenylpropanoyl)amino]prop-1-ynyl]-2-(hydroxymethyl)-4,4-dimethyl-5-oxopyrrolidine-2-carboxylate
• CAS: 1221973-73-4
• 化学式: C₂₃H₃₀N₂O₇
• 分子量: 446.5
• InChiKey: SZSPNLZAZVZEND-LQJGVCNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  145
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  methyl (3R,7S,7aR)-3-tert-butyl-7-hydroxy-7-[3-[(3-hydroxy-2,2-dimethyl-3-phenylpropanoyl)amino]prop-1-ynyl]-6,6-dimethyl-5-oxo-1,3-dihydropyrrolo[1,2-c][1,3]oxazole-7a-carboxylate 在 1,3-丙二硫醇 、 盐酸 、 水 作用下， 以 2,2,2-三氟乙醇 为溶剂， 反应 4.0h， 以65%的产率得到methyl (2R,3S)-3-hydroxy-3-[3-[(3-hydroxy-2,2-dimethyl-3-phenylpropanoyl)amino]prop-1-ynyl]-2-(hydroxymethyl)-4,4-dimethyl-5-oxopyrrolidine-2-carboxylate
  参考文献：
  名称：

  Oxazolomycins: Natural product lead structures for novel antibacterials by click fragment conjugation

  摘要：

  Conjugation of amide and lactam subunits by a 'Click' type approach provides access to structural mimics of the oxazolomycin series of natural products, some of which exhibit antibacterial activity. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.02.066

文献信息

• Oxazolomycins: Natural product lead structures for novel antibacterials by click fragment conjugation
  作者：Claire L. Bagwell、Mark G. Moloney、Muhammad Yaqoob

  DOI：10.1016/j.bmcl.2010.02.066

  日期：2010.4

  Conjugation of amide and lactam subunits by a 'Click' type approach provides access to structural mimics of the oxazolomycin series of natural products, some of which exhibit antibacterial activity. (C) 2010 Elsevier Ltd. All rights reserved.