methyl (2S)-2-[[chloro(ethenyl)phosphoryl]-prop-2-enylamino]-3-methylbutanoate | 400612-07-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S)-2-[[chloro(ethenyl)phosphoryl]-prop-2-enylamino]-3-methylbutanoate
• CAS: 400612-07-9
• 化学式: C₁₁H₁₉ClNO₃P
• 分子量: 279.704
• InChiKey: USFWWVFRJOEPOM-YOZOHBORSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl (2S)-2-[[chloro(ethenyl)phosphoryl]-prop-2-enylamino]-3-methylbutanoate 在 Grubbs catalyst first generation 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 (S)-2-{(S)-2-[(R)-1-((S)-1-Methoxycarbonyl-2-methyl-propyl)-2-oxo-2,5-dihydro-1H-2λ⁵-[1,2]azaphosphol-2-yloxy]-2-oxo-2,5-dihydro-2λ⁵-[1,2]azaphosphol-1-yl}-3-methyl-butyric acid methyl ester
  参考文献：
  名称：

  The Synthesis of P-Chiral Amino Acid-Derived Phosphonamidic Anhydrides

  摘要：

  The synthesis of an array of P-chiral amino acid-derived phosphonamidic anhydrides is described. These anhydrides are prepared by condensation of allylated amino acids 19-22 with methyl- or vinylphosphonic dichlorides 23 or 24 to produce three diastereomeric anhydrides 4-11a-c in good to excellent yields. The mechanistic issues concerning anhydride formation are discussed and supported by experimental results. Vinylphosphonamidic anhydrides 8-11 are further derivatized via the ring-closing metathesis (RCM) reaction to yield amino acid-derived bicyclic phosphonamidic anhydrides.

  DOI：

  10.1021/jo000631b
• 作为产物：
  描述：

  乙烯基膦酰氯 、 N-Allylated valine methyl ester 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 methyl (2S)-2-[[chloro(ethenyl)phosphoryl]-prop-2-enylamino]-3-methylbutanoate
  参考文献：
  名称：

  The Synthesis of P-Chiral Amino Acid-Derived Phosphonamidic Anhydrides

  摘要：

  The synthesis of an array of P-chiral amino acid-derived phosphonamidic anhydrides is described. These anhydrides are prepared by condensation of allylated amino acids 19-22 with methyl- or vinylphosphonic dichlorides 23 or 24 to produce three diastereomeric anhydrides 4-11a-c in good to excellent yields. The mechanistic issues concerning anhydride formation are discussed and supported by experimental results. Vinylphosphonamidic anhydrides 8-11 are further derivatized via the ring-closing metathesis (RCM) reaction to yield amino acid-derived bicyclic phosphonamidic anhydrides.

  DOI：

  10.1021/jo000631b