N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)phenoxy)pyridin-2-yl)-2-methoxyacetamide | 1229606-87-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)phenoxy)pyridin-2-yl)-2-methoxyacetamide
• 英文别名: N-[4-[4-[[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoylamino]phenoxy]pyridin-2-yl]-2-methoxyacetamide
• CAS: 1229606-87-4
• 化学式: C₂₉H₃₂N₆O₄
• 分子量: 528.611
• InChiKey: BMKVKXCWBWUXAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-(4-(4-aminophenoxy)pyridin-2-yl)-2-methoxyacetamide 、 N-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]imidazole-1-carboxamide 以 二氯甲烷 为溶剂， 生成 N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)phenoxy)pyridin-2-yl)-2-methoxyacetamide
  参考文献：
  名称：

  [EN] P38 MAP KINASE INHIBITORS
  [FR] INHIBITEURS DE KINASE MAP P38

  摘要：

  公开号：

  WO2010067130A8

文献信息

• INHIBITORS OF HEMOPOIETIC CELL KINASE (P59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION
  申请人：Charron Catherine Elisabeth

  公开号：US20120244120A1

  公开（公告）日：2012-09-27

  The present invention relates inter alia to the treatment or prevention of influenza virus infection (including subtypes influenza A virus, influenza B virus, avian strain H5N1, A/H1N1, H3N2 and/or pandemic influenza) using compounds which inhibit the activity of p59-HCK and to a method of screening for a candidate drug substance intended to prevent or treat influenza virus infection in a subject, said method comprising identifying a test substance capable of inhibiting p59-HCK activity.

  本发明涉及治疗或预防流感病毒感染（包括亚型流感A病毒、流感B病毒、禽流感H5N1、A/H1N1、H3N2和/或大流行性流感）的化合物，这些化合物抑制p59-HCK的活性，并涉及一种筛选候选药物物质的方法，该方法旨在预防或治疗受试者的流感病毒感染，所述方法包括识别能够抑制p59-HCK活性的试验物质。
• Inhibitors of Hemopoietic Cell Kinase (P59-HCK) and Their Use in the Treatment of Influenza Infection
  申请人：RESPIVERT LIMITED

  公开号：US20160045512A1

  公开（公告）日：2016-02-18

  The present invention relates inter alia to the treatment or prevention of influenza virus infection (including subtypes influenza A virus, influenza B virus, avian strain H5N1, A/H1N1, H3N2 and/or pandemic influenza) using compounds which inhibit the activity of p59-HCK and to a method of screening for a candidate drug substance intended to prevent or treat influenza virus infection in a subject, said method comprising identifying a test substance capable of inhibiting p59-HCK activity.

  本发明涉及治疗或预防流感病毒感染（包括亚型流感A病毒、流感B病毒、禽流感H5N1、A/H1N1、H3N2和/或大流行性流感）的化合物，这些化合物抑制p59-HCK的活性，并涉及一种筛选候选药物物质的方法，该方法旨在预防或治疗受试者的流感病毒感染，所述方法包括识别能够抑制p59-HCK活性的试验物质。
• UREIDO-PYRAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF RHINOVIRUS INFECTIONS
  申请人：Cass Lindsey

  公开号：US20130102607A1

  公开（公告）日：2013-04-25

  Medicinal use The disclosure relates to compounds of formula (I) for use in the treatment or prophylaxis of respiratory syncitial virus (RSV) infection in particular viral exacerbation of a respiratory disorder such as bronchitis, asthma, COPD and/or cystic fibrosis, methods of treating or preventing RSV infection employing said compounds or pharmaceutical composition comprising the same.

  药用途径：本公开涉及公式（I）的化合物，用于治疗或预防呼吸道合胞病毒(RSV)感染，特别是针对呼吸系统疾病如支气管炎、哮喘、慢性阻塞性肺疾病（COPD）和/或囊性纤维化的病毒加重的治疗，以及使用该化合物或含有该化合物的药物组合物进行治疗或预防RSV感染的方法。
• P38 MAP KINASE INHIBITORS
  申请人：Ito Kazuhiro

  公开号：US20110294812A1

  公开（公告）日：2011-12-01

  The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, including all stereoisomers, tautomers and isotopic derivatives thereof, which are inhibitors of p38 mitogen-activated protein kinase enzymes (referred to herein as p38 MAP kinase inhibitors), particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD.

  本发明涉及式（I）化合物：或其药学上可接受的盐，包括所有立体异构体、互变异构体和同位素衍生物，它们是p38丝裂原活化蛋白激酶酶（以下简称p38 MAP激酶抑制剂）的抑制剂，特别是其α和γ激酶亚型，并且它们在治疗中的使用，包括在药物组合中，特别是在治疗炎症性疾病方面的使用，包括肺部的炎症性疾病，如COPD。
• Insecticidal compositions and methods of using the same
  申请人：CLARKE MOSQUITO CONTROL PRODUCTS, INC.

  公开号：US10709139B2

  公开（公告）日：2020-07-14

  Insecticidal compositions have at least one active agent and at least one insecticide. The active agent can include perilla oil, a component found in perilla oil, or a perillaldehyde or carvone analog. The insecticide can include a pyrethrum, pyrethrin, pyrethroid, neonicotinoid, chlofenapyr, ethiprole, sulfoxoflor, carbamate, organophosphate, or organochlorine. Methods for controlling insects include contacting an insect with an effective amount of a composition described in this specification. Modified plants that produce an active agent can be contacted with an insecticide.

  杀虫组合物含有至少一种活性剂和至少一种杀虫剂。活性剂可包括紫苏油、紫苏油中的一种成分或紫苏醛或香芹酮类似物。杀虫剂可包括除虫菊酯、除虫菊酯、拟除虫菊酯、新烟碱类、氯虫苯甲酰胺、乙基吡咯、磺胺草醚、氨基甲酸酯、有机磷酸酯或有机氯。控制昆虫的方法包括使昆虫与有效量的本说明书所述组合物接触。可将产生活性剂的改良植物与杀虫剂接触。