4-(5-Methyl-1,3-thiazol-2-yl)piperidine | 1249151-01-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(5-Methyl-1,3-thiazol-2-yl)piperidine
• 英文别名: 5-methyl-2-piperidin-4-yl-1,3-thiazole
• CAS: 1249151-01-6
• 化学式: C₉H₁₄N₂S
• mdl: MFCD16834289
• 分子量: 182.29
• InChiKey: QWPOVXNYRVOVQQ-UHFFFAOYSA-N

物化性质

• 沸点：
  294.9±33.0 °C(Predicted)
• 密度：
  1.100±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE KINASE
  申请人：NUVATION BIO INC

  公开号：WO2021003314A1

  公开（公告）日：2021-01-07

  Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

  提供异环化合物作为CDK4或CDK6或其他CDK抑制剂。这些化合物可能作为治疗疾病的治疗剂，特别是在肿瘤学方面可能具有特殊用途。
• NOVEL COMPOUNDS
  申请人：GRAUERT Matthias

  公开号：US20130143870A1

  公开（公告）日：2013-06-06

  This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R 1 , R 2 , R 3 have meanings given in the description.

  这项发明涉及公式I的化合物，它们作为mGlu5受体活性的正向变构调节剂的用途，含有这些化合物的药物组合物，以及将其用作治疗和/或预防与谷氨酸功能障碍相关的神经和精神障碍，如精神分裂症或认知功能下降，如痴呆症或认知障碍的药剂的方法。A、B、X、R1、R2、R3在描述中给出了它们的含义。
• US8741892B2
  申请人：——

  公开号：US8741892B2

  公开（公告）日：2014-06-03
• [DE] PHENYL SUBSTITUIERTE HETEROARYL-DERIVATE UND DEREN VERWENDUNG ALS ANTITUMORMITTEL<br/>[EN] PHENYL SUBSTITUTED HETEROARYL-DERIVATIVES AND USE THEREOF AS ANTI-TUMOR AGENTS<br/>[FR] DÉRIVÉS D'HÉTÉROARYLE SUBSTITUÉS PAR PHÉNYLE ET LEUR UTILISATION EN TANT QU'AGENTS ANTITUMORAUX
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2008003770A1

  公开（公告）日：2008-01-10

  [EN] The invention relates to compounds of general formula (I), wherein the radicals R² to R⁴, L, Q and n are defined as indicated in claim 1. Said compounds are suitable for treating diseases that are characterised by excessive or anomal cell proliferation. The invention also relates to their use for producing a medicament having the above-mentioned properties.
  [FR] La présente invention concerne des composés de formule générale (1) dans laquelle les radicaux R^{2 à} R⁴, L, Q et n sont tels que définis dans la revendication 1. Ces composés conviennent pour le traitement de maladies qui se caractérisent par une prolifération cellulaire excessive ou anormale. L'invention a également pour objet l'utilisation de ces composés pour préparer un produit pharmaceutique ayant les propriétés sus-mentionnées.
  [DE] Die vorliegende Erfindung umfasst Verbindungen der allgemeinen Formel (I), wobei die Reste R² bis R⁴, L, Q und n wie in Anspruch 1 definiert sind, welche zur Behandlung von Krankheiten, die durch exzessive oder anomale Zellproliferation charakterisiert sind, geeignet sind, sowie deren Verwendung zur Herstellung eines Arzneimittels mit den vorstehend genannten Eigenschaften.
• [EN] COMPOSITION FOR DYEING KERATIN FIBRES, COMPRISING A PARTICULAR IMIDAZOLE COUPLER AND AN OXIDATION BASE<br/>[FR] COMPOSITION DE TEINTURE DE FIBRES DE KÉRATINE COMPRENANT UN COUPLEUR D'IMIDAZOLE PARTICULAIRE ET UNE BASE D'OXYDATION
  申请人：OREAL

  公开号：WO2015173321A1

  公开（公告）日：2015-11-19

  The invention relates to a composition comprising: i) at least one imidazole coupler of formula (I) with R1, R2 and R3 as defined in the description; ii) at least one oxidation base, preferably of heterocyclic and/or para-phenylenediamine type. The invention also relates to a process for dyeing keratin fibres using ingredients i) and ii); to a kit comprising ingredients i) and ii) and to the use of ingredient i) combined with ii) for dyeing keratin fibres, and to novel couplers. The composition of the invention leads to particularly powerful, chromatic and sparingly selective colourings. Furthermore, the colour build-up on keratin fibres treated with the composition of the invention is very satisfactory.