[4-(4-Chlorophenyl)-6-(3,4-dimethoxyphenyl)pyrimidin-2-yl]urea | 1229405-53-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: [4-(4-Chlorophenyl)-6-(3,4-dimethoxyphenyl)pyrimidin-2-yl]urea
• CAS: 1229405-53-1
• 化学式: C₁₉H₁₇ClN₄O₃
• 分子量: 384.822
• InChiKey: DKHFTFJFOBRSCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  99.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [4-(4-Chlorophenyl)-6-(3,4-dimethoxyphenyl)pyrimidin-2-yl]urea 在 一水合肼 作用下， 以 乙醇 为溶剂， 生成 1-Amino-3-[4-(4-chlorophenyl)-6-(3,4-dimethoxyphenyl)pyrimidin-2-yl]urea
  参考文献：
  名称：

  Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives

  摘要：

  A number of N-(4,6-substituted diphenylpyrimidin-2-yl) semicarbazones (4a-t) were synthesized and tested for their anticonvulsant activity against the two seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) All the synthesized compounds possessed the four essential pharmacophoric elements for good anticonvulsant activity. Most of the compounds displayed good anticonvulsant activity with lesser neurotoxicity. To assess the unwanted effects of the compounds on liver, estimation of enzymes and proteins was carried out.

  DOI：

  10.1016/j.ejmech.2010.02.031
• 作为产物：
  描述：

  4-(4-chlorophenyl)-6-(3,4-dimethoxyphenyl)pyrimidin-2-amine 、 sodium isocyanate 在 溶剂黄146 作用下， 以 乙醇 、 水 为溶剂， 生成 [4-(4-Chlorophenyl)-6-(3,4-dimethoxyphenyl)pyrimidin-2-yl]urea
  参考文献：
  名称：

  Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives

  摘要：

  A number of N-(4,6-substituted diphenylpyrimidin-2-yl) semicarbazones (4a-t) were synthesized and tested for their anticonvulsant activity against the two seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) All the synthesized compounds possessed the four essential pharmacophoric elements for good anticonvulsant activity. Most of the compounds displayed good anticonvulsant activity with lesser neurotoxicity. To assess the unwanted effects of the compounds on liver, estimation of enzymes and proteins was carried out.

  DOI：

  10.1016/j.ejmech.2010.02.031

文献信息

• Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives
  作者：Ozair Alam、Pooja Mullick、S.P. Verma、Sadaf J. Gilani、Suroor A. Khan、Nadeem Siddiqui、Waquar Ahsan

  DOI：10.1016/j.ejmech.2010.02.031

  日期：2010.6

  A number of N-(4,6-substituted diphenylpyrimidin-2-yl) semicarbazones (4a-t) were synthesized and tested for their anticonvulsant activity against the two seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) All the synthesized compounds possessed the four essential pharmacophoric elements for good anticonvulsant activity. Most of the compounds displayed good anticonvulsant activity with lesser neurotoxicity. To assess the unwanted effects of the compounds on liver, estimation of enzymes and proteins was carried out.