methyl 5-amino-8-propyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole-7-carboxylate | 1429219-70-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: methyl 5-amino-8-propyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole-7-carboxylate
• CAS: 1429219-70-4
• 化学式: C₁₉H₂₄N₄O₃
• 分子量: 356.425
• InChiKey: VCGMLUAUPKIEAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.54
• 重原子数：
  26.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  95.16
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  methyl 5-amino-8-propyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole-7-carboxylate 在 盐酸 作用下， 以 水 为溶剂， 反应 1.5h， 以23%的产率得到
  参考文献：
  名称：

  Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors

  摘要：

  The synthesis and Pim kinase inhibition potency of a new series of pyrrolo[2,3-g] indazole derivatives is described. The results obtained in this preliminary structure-activity relationship study pointed out that sub-micromolar Pim-1 and Pim-3 inhibitory potencies could be obtained in this series, more particularly for compounds 10 and 20, showing that pyrrolo[2,3-g] indazole scaffold could be used for the development of new potent Pim kinase inhibitors. Molecular modeling experiments were also performed to study the binding mode of these compounds in Pim-3 ATP-binding pocket. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.02.074
• 作为产物：
  描述：

  methyl 5-nitro-8-propyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole-7-carboxylate 在 platinum(IV) oxide 、 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 12.0h， 以77%的产率得到methyl 5-amino-8-propyl-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyrrolo[2,3-g]indazole-7-carboxylate
  参考文献：
  名称：

  Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors

  摘要：

  The synthesis and Pim kinase inhibition potency of a new series of pyrrolo[2,3-g] indazole derivatives is described. The results obtained in this preliminary structure-activity relationship study pointed out that sub-micromolar Pim-1 and Pim-3 inhibitory potencies could be obtained in this series, more particularly for compounds 10 and 20, showing that pyrrolo[2,3-g] indazole scaffold could be used for the development of new potent Pim kinase inhibitors. Molecular modeling experiments were also performed to study the binding mode of these compounds in Pim-3 ATP-binding pocket. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.02.074