5-{[4-(3-methyl-1,2,4-oxadiazole-5-yl)benzyl]thio}-1H-1,2,4-triazole-3-amine | 672907-78-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-{[4-(3-methyl-1,2,4-oxadiazole-5-yl)benzyl]thio}-1H-1,2,4-triazole-3-amine
• 英文别名: 3-[[4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]methylsulfanyl]-1H-1,2,4-triazol-5-amine
• CAS: 672907-78-7
• 化学式: C₁₂H₁₂N₆OS
• 分子量: 288.333
• InChiKey: OVUGMKRQQPIVJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• METHOD OF SCREENING INSULIN CONTENT ENHANCER
  申请人：YAMANOUCHI PHARMACEUTICAL CO., LTD.

  公开号：EP1538217A1

  公开（公告）日：2005-06-08

  A screening tool for an agent for promoting insulin production and/or an agent for increasing insulin content, wherein the tool is a G protein-coupled receptor exhibiting an activity of promoting insulin production by activation, or a cell expressing the polypeptide, is disclosed. Further, a method for screening an agent for promoting insulin production and/or an agent for increasing insulin content, comprising the steps of bringing the cell or a cell membrane thereof into contact with a substance to be tested, and analyzing whether or not the polypeptide is activated, is disclosed. The screening tool and the screening method are useful in screening a substance which increases insulin content and prevents and/or treats diabetes. Furthermore, a novel agent for increasing insulin content comprising as an active ingredient a substance obtained by the screening, is disclosed.

  本发明公开了一种促进胰岛素分泌的制剂和/或增加胰岛素含量的制剂的筛选工具，其中该工具是表现出通过激活促进胰岛素分泌活性的G蛋白偶联受体，或表达多肽的细胞。此外，还公开了一种用于筛选促进胰岛素分泌的制剂和/或增加胰岛素含量的制剂的方法，该方法包括以下步骤：使细胞或其细胞膜与待测物质接触，并分析多肽是否被激活。 该筛选工具和筛选方法有助于筛选出一种能增加胰岛素含量、预防和/或治疗糖尿病的物质。 此外，还公开了一种增加胰岛素含量的新型制剂，其活性成分包括通过筛选获得的物质。
• Method of screening insulin content enhancer
  申请人：Ohishi Takahide

  公开号：US20050191612A1

  公开（公告）日：2005-09-01

  A screening tool for an agent for promoting insulin production and/or an agent for increasing insulin content, wherein the tool is a G protein-coupled receptor exhibiting an activity of promoting insulin production by activation, or a cell expressing the polypeptide, is disclosed. Further, a method for screening an agent for promoting insulin production and/or an agent for increasing insulin content, comprising the steps of bringing the cell or a cell membrane thereof into contact with a substance to be tested, and analyzing whether or not the polypeptide is activated, is disclosed. The screening tool and the screening method are useful in screening a substance which increases insulin content and prevents and/or treats diabetes. Furthermore, a novel agent for increasing insulin content comprising as an active ingredient a substance obtained by the screening, is disclosed.