N-(4-bromo-2-(trifluoromethoxy)benzyl)-1-((3-ethyl-1,2,4-oxadiazol-5-yl)methyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide | 1254837-15-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(4-bromo-2-(trifluoromethoxy)benzyl)-1-((3-ethyl-1,2,4-oxadiazol-5-yl)methyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide
• 英文别名: N-[[4-bromo-2-(trifluoromethoxy)phenyl]methyl]-3-[(3-ethyl-1,2,4-oxadiazol-5-yl)methyl]-2,4-dioxo-1H-pyrimidine-6-carboxamide
• CAS: 1254837-15-4
• 化学式: C₁₈H₁₅BrF₃N₅O₅
• 分子量: 518.247
• InChiKey: LMYUHPFMJMFPGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  (4-bromo-2-(trifluoromethoxy)phenyl)methanamine hydrochloride 、 1-((3-ethyl-1,2,4-oxadiazol-5-yl)methyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid 在 N-甲基吗啉 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-(4-bromo-2-(trifluoromethoxy)benzyl)-1-((3-ethyl-1,2,4-oxadiazol-5-yl)methyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide
  参考文献：
  名称：

  [EN] 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES
  [FR] 2,6-DIOXO-1, 2, 3, 6-TÉTRAHYDROPYRIMIDINE-4-CARBOXAMIDES

  摘要：

  公开号：

  WO2010129848A3

文献信息

• POLYESTER COPOLYMER
  申请人：MITSUBISHI RAYON CO., LTD.

  公开号：EP0483354A1

  公开（公告）日：1992-05-06

  The title copolymer is obtained by reacting a dicarboxylic acid component mainly composed of terephthalic acid or its derivative with a glycol component composed of 0.5 mol % or more and less than 15 mole % of an aliphatic diol having 2 to 16 carbon atoms and more than 85 mol % and not more than 99.5 mol % of 1,4-cyclohexanedimethanol at least 80 mol % of which is in the trans form. This polyester copolymer has a high crystallization rate and an excellent heat resistance.

  将主要由对苯二甲酸或其衍生物组成的二羧酸组分与由 0.5 摩尔%或更多但少于 15 摩尔%的具有 2 至 16 个碳原子的脂肪族二元醇和超过 85 摩尔%但不超过 99.5 摩尔%的 1,4-环己烷二甲醇（其中至少 80 摩尔%为反式）组成的乙二醇组分反应，即可得到上述共聚物。这种聚酯共聚物具有较高的结晶率和出色的耐热性。
• CLOGGING INHIBITOR FOR OIL FILTERS, METHOD FOR INHIBITING THE CLOGGING OF OIL FILTERS AND ENGINE OIL COMPOSITIONS CONTAINING THE INHIBITOR
  申请人：NEW JAPAN CHEMICAL CO.,LTD.

  公开号：EP1205535A1

  公开（公告）日：2002-05-15

  Disclosed are an agent for preventing clogging of oil filters for various internal combustion engines, the agent comprising at least one hydroxyl-containing component selected from the group consisting of: compounds represented by the formula (1)         R1O― (R2O) m―H   (1) wherein R1 is hydrogen or C1 to C8 alkyl, R2 is C2 to C10 alkylene, m is an integer of 1 to 10, and when m is 2 or more, the two or more R2 groups may be the same or different; and compounds represented by the formula (2) wherein R3 is C2 to C4 alkylene, R4 is hydrogen or C1 to C10 alkyl, n is an integer of 0 to 8, and when n is 2 or more, the two or more R3 groups may be the same or different; a method for preventing oil filter clogging using the oil filter clogging preventing agent, and an engine oil composition containing the oil filter clogging preventing agent.

  本发明公开了一种用于防止各种内燃机滤油器堵塞的药剂，该药剂包含至少一种含羟基的成分，该成分选自由以下组成的组： 由式 (1) 代表的化合物 R1O- (R2O) m-H (1) 其中 R1 为氢或 C1 至 C8 烷基，R2 为 C2 至 C10 亚烷基，m 为 1 至 10 的整数，当 m 为 2 或更大时，两个或多个 R2 基团可以相同或不同；以及 式 (2) 所代表的化合物 其中 R3 为 C2 至 C4 亚烷基，R4 为氢或 C1 至 C10 烷基，n 为 0 至 8 的整数，当 n 为 2 或更多时，两个或多个 R3 基团可以相同或不同；使用机油滤清器堵塞防止剂防止机油滤清器堵塞的方法，以及含有机油滤清器堵塞防止剂的发动机油组合物。
• PROCESS FOR PRODUCING POWDER COATING COMPOSITION, POWDER COATING COMPOSITION, AND METHOD OF COATING FILM FORMATION
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP1211296A1

  公开（公告）日：2002-06-05

  A powder coating is provided which does not require a long complicated production process, can be produced easily and with no danger of gelling occurring during production, and which forms a paint film with superior smoothness and with no film defects such as bubbles or pinholes. A powder coating raw materials solution comprising as essential constituents a room temperature solid main constituent resin (A) with a curable reactive group, a room temperature solid curing agent (B) which reacts with the curable reactive group of the main constituent resin (A), and an organic solvent (C), is spray dried at a temperature at which the main constituent resin (A) and the curing agent (B) undergo no substantial curing reaction.

  本发明提供了一种粉末涂料，它不需要复杂的长期生产工艺，可以轻松生产，并且在生产过程中不会出现胶凝的危险，形成的漆膜具有极佳的平滑性，不会出现气泡或针孔等漆膜缺陷。粉末涂料原料溶液的基本成分包括具有可固化反应基的室温固体主成分树脂（A）、与主成分树脂（A）的可固化反应基反应的室温固体固化剂（B）和有机溶剂（C），在主成分树脂（A）和固化剂（B）不发生实质性固化反应的温度下进行喷雾干燥。
• POROUS TITANIUM OXIDE POWDER AND METHOD FOR PRODUCTION THEREOF
  申请人：Shiseido Co., Ltd.

  公开号：EP1616840A1

  公开（公告）日：2006-01-18

  There is provided a titanium oxide powder having excellent ultraviolet-protecting ability, usability and transparency, and a method of manufacturing the same. The titanium oxide powder provided is a porous titanium oxide powder that is formed from titanium oxide primary particles agglomerated together, has a mean particle diameter of 0.01 to 100 µm, and has a specific surface area of 250 to 500 m2/g. The porous titanium oxide powder can be obtained by subjecting a titanium salt solution to hydrolysis by heating under the presence of an aliphatic alcohol and/or a substance having a carboxyl group or a carbonyl group, and then further carrying out heating treatment with an acid. The titanium oxide primary particles preferably have a mean particle diameter of 1 to 50 nm, and the powder preferably has an approximately spherical shape with the ratio of the minor axis to the major axis being at least 0.75 .

  本发明提供了一种具有优异紫外线防护能力、可用性和透明度的氧化钛粉末及其制造方法。所提供的氧化钛粉末是一种多孔氧化钛粉末，它是由氧化钛初级粒子团聚在一起形成的，平均粒子直径为 0.01 至 100 微米，比表面积为 250 至 500 平方米/克。多孔氧化钛粉末可通过在脂肪醇和/或具有羧基或羰基的物质存在下加热水解钛盐溶液，然后进一步用酸进行加热处理而获得。氧化钛初级粒子的平均粒径最好为 1 至 50 纳米，粉末最好呈近似球形，小轴与大轴之比至少为 0.75。
• POWDERY TITANIUM OXIDE-ZINC OXIDE AGGREGATE, AND PROCESS FOR PRODUCTION THEREOF
  申请人：Shiseido Company, Limited

  公开号：EP2050719A1

  公开（公告）日：2009-04-22

  The present invention provides a powder that can display excellent protection ability in both UV-A and UV-B regions. The titanium oxide-zinc oxide aggregate powder comprises an aggregate formed by the aggregation of porous titanium oxide particles and zinc oxide particles, and said porous titanium oxide particle is an aggregate of primary fine particles of titanium oxide. The production method of the titanium oxide-zinc oxide aggregate powder comprises the steps of: (a) hydrolyzing, with heating, an aqueous solution containing a titanium salt and an aliphatic alcohol; (b) adding a water-soluble zinc salt to a suspension of a precipitate obtained by the hydrolysis with heating in step (a), and then neutralizing the suspension with an alkali; and (c) calcining a precipitate obtained by the neutralization in step (b).

  本发明提供了一种在紫外线-A 和紫外线-B 区域都能显示出卓越防护能力的粉末。该氧化钛-氧化锌聚合粉末包括多孔氧化钛颗粒和氧化锌颗粒聚合而成的聚合体，所述多孔氧化钛颗粒是初级细小氧化钛颗粒的聚合体。氧化钛-氧化锌聚合粉末的生产方法包括以下步骤(a) 加热水解含有钛盐和脂肪醇的水溶液；(b) 向步骤(a)中加热水解得到的沉淀的悬浮液中加入水溶性锌盐，然后用碱中和悬浮液；(c) 煅烧步骤(b)中和得到的沉淀。