(2S,4S)-N-benzyloxycarbonyl-4-formyloxyproline methyl ester | 170159-62-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,4S)-N-benzyloxycarbonyl-4-formyloxyproline methyl ester
• 英文别名: 1-O-benzyl 2-O-methyl (2S,4S)-4-formyloxypyrrolidine-1,2-dicarboxylate
• CAS: 170159-62-3
• 化学式: C₁₅H₁₇NO₆
• 分子量: 307.303
• InChiKey: FZYGQTCGFVPQKD-STQMWFEESA-N

物化性质

• 沸点：
  425.3±45.0 °C(Predicted)
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  82.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2S,4S)-N-benzyloxycarbonyl-4-formyloxyproline methyl ester 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以92%的产率得到(2S,4S)-1-(苄基羰基)-4-羟基吡咯烷-2-羧酸
  参考文献：
  名称：

  Seki, Masahiko; Matsumoto, Kazuo, Bioscience, Biotechnology and Biochemistry, 1995, vol. 59, # 6, p. 1161 - 1162

  摘要：

  DOI：
• 作为产物：
  描述：

  氯甲酸苄酯 在 氯化亚砜 、 碳酸氢钠 、 N,N'-二环己基碳二亚胺 、 copper(l) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 106.0h， 生成 (2S,4S)-N-benzyloxycarbonyl-4-formyloxyproline methyl ester
  参考文献：
  名称：

  Seki, Masahiko; Matsumoto, Kazuo, Bioscience, Biotechnology and Biochemistry, 1995, vol. 59, # 6, p. 1161 - 1162

  摘要：

  DOI：

文献信息

• Heterocyclic Compounds and Methods of Their Use
  申请人：Spinifex Pharmaceuticals Pty Ltd

  公开号：US20140378430A1

  公开（公告）日：2014-12-25

  The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT 2 ) receptor. More particularly the invention relates to pyrrolidine and azetidine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT 2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.
• HETEROCYCLIC COMPOUNDS AND METHODS OF THEIR USE
  申请人：NOVARTIS AG

  公开号：US20170145032A1

  公开（公告）日：2017-05-25

  The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT 2 ) receptor. More particularly the invention relates to pyrrolidine and azetidine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT 2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.
• US9624243B2
  申请人：——

  公开号：US9624243B2

  公开（公告）日：2017-04-18