Boc-Arg-Gly-OBzl | 1445013-24-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Arg-Gly-OBzl
• CAS: 1445013-24-0
• 化学式: C₂₀H₃₁N₅O₅
• 分子量: 421.497
• InChiKey: QJPMOFUKQYIZKF-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.0
• 重原子数：
  30.0
• 可旋转键数：
  10.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  155.63
• 氢给体数：
  5.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  Boc-Arg-Gly-OBzl 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以1.332 g的产率得到N-(N^α-tert-butyloxycarbonyl-L-arginyl)glycine hydrochloride
  参考文献：
  名称：

  Design and photophysical properties of new RGD targeted tetraphenylchlorins and porphyrins

  摘要：

  The synthesis, characterization, fluorescence, and singlet oxygen quantum yields of tetraphenylporphyrin and tetraphenylchlorin coupled to RGD type peptide are reported. C-terminus protected RGD derivatives were synthesized in liquid phase at the gram scale via an efficient convergent process. C-terminus unprotected RGD derivatives were synthesized on solid support. The UV-vis, fluorescence, and singlet emission spectra showed that the photophysical properties of the photosensitizers were retained in all compounds and some of them are very promising for potential PDT applications. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.01.142
• 作为产物：
  描述：

  N-Boc-L-精氨酸 、 甘氨酸苄酯盐酸盐 在 1-羟基苯并三唑一水物 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成 Boc-Arg-Gly-OBzl
  参考文献：
  名称：

  Design and photophysical properties of new RGD targeted tetraphenylchlorins and porphyrins

  摘要：

  The synthesis, characterization, fluorescence, and singlet oxygen quantum yields of tetraphenylporphyrin and tetraphenylchlorin coupled to RGD type peptide are reported. C-terminus protected RGD derivatives were synthesized in liquid phase at the gram scale via an efficient convergent process. C-terminus unprotected RGD derivatives were synthesized on solid support. The UV-vis, fluorescence, and singlet emission spectra showed that the photophysical properties of the photosensitizers were retained in all compounds and some of them are very promising for potential PDT applications. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.01.142