4-methyl-N-(2-(1-(pyrrolidin-1-yl)allyl)phenyl)benzenesulfonamide | 1174333-11-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-(2-(1-(pyrrolidin-1-yl)allyl)phenyl)benzenesulfonamide
• CAS: 1174333-11-9
• 化学式: C₂₀H₂₄N₂O₂S
• 分子量: 356.489
• InChiKey: HIEYVIUSOGYEJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.12
• 重原子数：
  25.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.41
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 1-tosyl-4-vinyl-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one 在 四(三苯基膦)钯 作用下， 以 甲苯 为溶剂， 以97%的产率得到4-methyl-N-(2-(1-(pyrrolidin-1-yl)allyl)phenyl)benzenesulfonamide
  参考文献：
  名称：

  Decarboxylative cyclizations and cycloadditions of palladium-polarized aza-ortho-xylylenes

  摘要：

  Vinyl benzoxazinones undergo decarboxylation in the presence of palladium catalysts to form palladium-polarized aza-ortho-xylylenes, which are versatile reaction intermediates. These palladium-polarized aza-ortho-xylylenes are generated under exceptionally mild conditions and undergo a plethora of different reactions depending on the reaction conditions. Specifically, they undergo dimerization reactions to produce macrocycles, cyclizations to form dihydroquinolines, cycloadditions with electrophilic p-bonds, and nucleophilic attack by amines. Thus, a wide array of structurally unique aniline derivatives can be accessed from these unique intermediates. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.04.071