3-[N-(tert-butoxycarbonyl)-D-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione | 642471-93-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[N-(tert-butoxycarbonyl)-D-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione
• CAS: 642471-93-0
• 化学式: C₂₉H₃₀N₂O₇S
• 分子量: 550.632
• InChiKey: XWQMEFSYJONKKG-CUXXENAFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.62
• 重原子数：
  39.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  127.87
• 氢给体数：
  2.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  3-[N-(tert-butoxycarbonyl)-D-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 以96%的产率得到3-(D-phenylalanyl)amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione hydrochloride
  参考文献：
  名称：

  New benzo[g]isoquinoline-5,10-diones and dihydrothieno [2,3-b]naphtho-4,9-dione derivatives

  摘要：

  Novel antitumoral agents with quinonic structure were synthesized and evaluated for their in vitro cytotoxic activities. This study examines the cytotoxic activities of several aryl benzo[g]isoquinoline-5,10-dione derivatives and a number of aminoacyl dihydrothieno[2,3-b]naphtho-4.9-dione (DTNQ) derivatives containing amino acids in position 3 of the ring system. Compound 6 showed remarkable cytotoxic activity at submicromolar concentration not only against several human leukaemia and solid tumour cell lines, but also toward sensitive and resistant human cell lines. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00310-9
• 作为产物：
  描述：

  在 1-羟基苯并三唑 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 N,N-二异丙基乙胺 、 silver carbonate 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 13.0h， 生成 3-[N-(tert-butoxycarbonyl)-D-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione
  参考文献：
  名称：

  New benzo[g]isoquinoline-5,10-diones and dihydrothieno [2,3-b]naphtho-4,9-dione derivatives

  摘要：

  Novel antitumoral agents with quinonic structure were synthesized and evaluated for their in vitro cytotoxic activities. This study examines the cytotoxic activities of several aryl benzo[g]isoquinoline-5,10-dione derivatives and a number of aminoacyl dihydrothieno[2,3-b]naphtho-4.9-dione (DTNQ) derivatives containing amino acids in position 3 of the ring system. Compound 6 showed remarkable cytotoxic activity at submicromolar concentration not only against several human leukaemia and solid tumour cell lines, but also toward sensitive and resistant human cell lines. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00310-9

文献信息

• Cycloaddition reactions of thiazolidine derivatives. An approach to the synthesis of new functionalized heterocyclic systems
  作者：Isabel M Gomez-Monterrey、Pietro Campiglia、Orazio Mazzoni、Ettore Novellino、M.Vittoria Diurno

  DOI：10.1016/s0040-4039(01)01035-8

  日期：2001.8

  10-dione and dihydrothieno[2,3-b]naphto-4,9-dione (DTNQ) is described. These new series were synthesized from cycloaddition reactions between naphthoquinone and arylthiazolidine derivatives, the latter acting, respectively, as highly reactive N-arylidenedehydroalanine ethyl esters (2-AD) or as amino ester nucleophilic species.

  描述了一种一锅法，用于合成具有苯并[ g ]异喹啉-5,10-二酮和二氢噻吩并[2,3 - b ]萘-4,9-二酮（DTNQ）结构的两个官能化三环系统。这些新系列是由萘醌和芳基噻唑烷衍生物之间的环加成反应合成的，后者分别作为高反应性N-芳基二氢丙氨酸乙酯（2-AD）或作为氨基酯亲核物质。