3-[3,5-Bis[1-[3,5-bis(3-aminopropoxy)phenyl]triazol-4-yl]phenoxy]propan-1-amine | 1443620-30-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[3,5-Bis[1-[3,5-bis(3-aminopropoxy)phenyl]triazol-4-yl]phenoxy]propan-1-amine
• CAS: 1443620-30-1
• 化学式: C₃₇H₅₁N₁₁O₅
• 分子量: 729.883
• InChiKey: YTJHSAHPCFUSHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  53
• 可旋转键数：
  24
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  238
• 氢给体数：
  5
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以84%的产率得到3-[3,5-Bis[1-[3,5-bis(3-aminopropoxy)phenyl]triazol-4-yl]phenoxy]propan-1-amine
  参考文献：
  名称：

  [EN] CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
  [FR] COMPOSÉS CYCLIQUES ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION

  摘要：

  本发明提供了用于抑制微生物生长的化合物或其药学上可接受的盐；用于治疗患有微生物感染、口腔炎、眼科感染、耳科感染、癌症或结核分枝杆菌感染的哺乳动物；用于抑制结核分枝杆菌物种的生长；用于调节哺乳动物的免疫反应；或用于拮抗非分级肝素、低分子肝素或肝素/低分子肝素衍生物。

  公开号：

  WO2013090185A1

文献信息

• CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
  申请人：Cellceutix Corporation

  公开号：US20150031738A1

  公开（公告）日：2015-01-29

  The present invention provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.

  本发明提供化合物或其药学上可接受的盐，用于抑制微生物的生长；治疗患有微生物感染、口腔炎症、眼部感染、耳部感染、癌症或分枝杆菌感染的哺乳动物；抑制分枝杆菌属的生长；调节哺乳动物的免疫反应；或拮抗非分散肝素、低分子量肝素或肝素/低分子量肝素衍生物。
• Compounds And Methods For Treating Candidiasis And Aspergillus Infections
  申请人：Scott Richard W.

  公开号：US20130252964A1

  公开（公告）日：2013-09-26

  The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for killing or inhibiting the growth of a Candida or Aspergillus species or preventing or treating a mammal having candidiasis (oral and/or disseminated) or an Aspergillus infection.
• COMPOUNDS AND METHODS FOR TREATING CANDIDIASIS AND ASPERGILLUS INFECTIONS
  申请人：Cellceutix Corporation

  公开号：US20160287586A1

  公开（公告）日：2016-10-06

  The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for killing or inhibiting the growth of a Candida or Aspergillus species or preventing or treating a mammal having candidiasis (oral and/or disseminated) or an Aspergillus infection.
• US9469616B2
  申请人：——

  公开号：US9469616B2

  公开（公告）日：2016-10-18
• [EN] COMPOUNDS AND METHODS FOR TREATING CANDIDIASIS AND ASPERGILLUS INFECTIONS<br/>[FR] COMPOSÉS ET MÉTHODES PERMETTANT DE TRAITER CANDIDOSES ET INFECTIONS À ASPERGILLUS
  申请人：POLYMEDIX INC

  公开号：WO2013109827A1

  公开（公告）日：2013-07-25

  The present disclosure provides facially arnphiphilic antimicrobial oligomers, pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, useful for killing or inhibiting the growth of a Candida or Aspergillus species, as well as preventing or treating a mammal having oral or disseminated candidiasis or an aspergillus infection. The method(s) employed comprise(s) contacting the Candida or Aspergillus species with or administering to the mammal in need thereof an effective amount of such an antimicrobial oligomer, pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof.