2,4-dinitro-N-propargylaniline | 75077-45-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dinitro-N-propargylaniline
• 英文别名: 2,4-dinitro-N-(prop-2-ynyl)aniline；N-(2-Propynyl)-2,4-dinitroaniline；2,4-dinitro-N-prop-2-ynylaniline
• CAS: 75077-45-1
• 化学式: C₉H₇N₃O₄
• mdl: MFCD01364807
• 分子量: 221.172
• InChiKey: MVSHOHFTBBBTLR-UHFFFAOYSA-N

物化性质

• 熔点：
  157-158 °C
• 沸点：
  402.9±45.0 °C(Predicted)
• 密度：
  1.480±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,4-dinitro-N-propargylaniline 在 镍 氢气 、 tetrakis(acetonitrile)copper(I) tetrafluoroborate 、 一水合肼 作用下， 以 乙醇 、 1,2-二氯乙烷 、 甲苯 为溶剂， 60.0~90.0 ℃ 、101.33 kPa 条件下， 反应 24.5h， 生成 3-甲基-6-喹喔啉胺
  参考文献：
  名称：

  铜（I）合成食物诱变剂MelQx和4,8-DiMelQx促进喹喔啉的形成

  摘要：

  描述了标题化合物（1和2）的区域控制合成。关键步骤是通过四（乙腈）铜（I）四氟硼酸酯实现新的分子内炔烃胺化和芳构化过程（5 → 6 ; 8 → 9）。

  DOI：

  10.1016/0040-4020(89)80127-9
• 作为产物：
  描述：

  1-氯-2,4-二硝基苯 、 炔丙胺 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 2,4-dinitro-N-propargylaniline
  参考文献：
  名称：

  铜（I）合成食物诱变剂MelQx和4,8-DiMelQx促进喹喔啉的形成

  摘要：

  描述了标题化合物（1和2）的区域控制合成。关键步骤是通过四（乙腈）铜（I）四氟硼酸酯实现新的分子内炔烃胺化和芳构化过程（5 → 6 ; 8 → 9）。

  DOI：

  10.1016/0040-4020(89)80127-9

文献信息

• COVALENT IMMUNE RECRUITER COMPOUNDS FOR IMMUNE CELL RECOGNITION AND ASSOCIATED USES
  申请人：McMaster University

  公开号：US20210276981A1

  公开（公告）日：2021-09-09

  The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies. ABD−(L 1 ) n -ALD-(L 2 )m-R

  本申请涉及一种公式I的化合物，包括含有与受体结合的抗体结合域（ABD）的化合物，该抗体包括一个与抗体中的一个受体结合位点结合的半抗原，一个含有与接近半抗原结合位点的氨基酸形成共价键的功能基团的抗体标记域（ALD），以及共价键的形成导致ABD的消除和目标结合域（TBD）或检测物结合域（DMD），每个域可以选择独立连接的连接物。本申请还包括该化合物的方法和用途，例如，通过招募标记抗体对目标细胞进行免疫识别的方法。ABD−（L1）n-ALD-（L2）m-R
• Novel nonlinear optical materials and processes employing diacetylenes
  申请人：University Patents, Inc.

  公开号：US04431263A1

  公开（公告）日：1984-02-14

  Novel nonlinear optical, piezoelectric, pyroelectric, waveguide, and other materials are presented together with processes for their employment and articles formed thereby. Such materials, processes and articles comprise diacetylenes and polymers formed from diacetylenic species, which polymers are amenable to close geometric, steric, structural, and electronic control. Accordingly, it is now possible to design, formulate and employ new diacetylenic species and polymers formed therefrom to provide nonlinear optic, waveguide, piezoelectric, and pyroelectric materials and devices having surprising efficiencies and degrees of effect. According to a preferred embodiment of the invention, diacetylenes which are crystallizable into crystals having a noncentrosymmetric unit cell may form single crystals or may be elaborated into a thin film upon a substrate by the Langmuir-Blodgett technique. Such films may, optionally, be polymerized either thermally or by irradiation for use in nonlinear optical and other systems. According to other preferred embodiments, diacetylenes are covalently bonded to substrates through the employment of silane species and subsequently polymerized to yield nonlinear optic and other devices having high structural integrity in addition to high efficiencies and effects.

  本发明提供了新型非线性光学、压电、热释电、波导和其他材料，以及它们的使用过程和由此形成的文章。这些材料、过程和文章包括由二乙炔基物种形成的二乙炔烯和聚合物，这些聚合物易于进行几何、立体、结构和电子控制。因此，现在可以设计、配制和使用新的二乙炔基物种和由此形成的聚合物，以提供具有惊人效率和效果的非线性光学、波导、压电和热释电材料和设备。根据本发明的一种优选实施方式，可结晶成具有非中心对称晶胞的晶体的二乙炔烯可以形成单晶，或通过Langmuir-Blodgett技术制成薄膜。这些薄膜可以选择性地通过热或辐射聚合，用于非线性光学和其他系统。根据其他优选实施方式，通过使用硅烷物种将二乙炔烯共价键合到基底上，并随后聚合，以产生具有高结构完整性以及高效率和效果的非线性光学和其他设备。
• Photoresistive compositions
  申请人：University Patents, Inc.

  公开号：US04439514A1

  公开（公告）日：1984-03-27

  Photographic and Photolithographic systems are provided which utilize diacetylenic materials as components thereof. Such materials, which include at least two acetylenic bonds in conjugation with one another, provide a combination of both high sensitivity and high resolving power, thus resulting in superior photographic and photolithographic properties. In accordance with a preferred embodiment of the invention, a substrate is coated with at least one layer of a polymerizable composition comprising a diacetylenic species, said layer being organized into a plurality of domains having a substantially regular array of the diacetylenic species. In other embodiments, covalent bonding of the diacetylenic layer to the substrate is accomplished through the use of suitably constituted silane species, thus to provide a highly beneficial adhesion of substrate and photo- or photolithographic layer.

  提供了利用二乙炔基材料作为其组分的摄影和光刻系统。这些材料包括至少两个相互共轭的乙炔键，提供了高灵敏度和高分辨率的组合，从而导致卓越的摄影和光刻特性。根据发明的优选实施例，基底被涂覆至少一层聚合物化合物，其中包含二乙炔基物种，该层被组织成具有二乙炔基物种的基本规则阵列的多个域。在其他实施例中，通过使用适当构成的硅烷物种实现二乙炔基层与基底的共价键结合，从而提供了基底和光刻层之间高度有益的粘附。
• Nonlinear optical materials and processes employing diacetylenes
  申请人：University Patents, Inc.

  公开号：US04536450A1

  公开（公告）日：1985-08-20

  Novel nonlinear optical, piezoelectric, pyroelectric, waveguide, and other materials are presented together with processes for their employment and articles formed thereby. Such materials, processes and articles comprise diacetylenes and polymers formed from diacetylenic species, which polymers are amenable to close geometric, steric, structural, and electronic control. Accordingly, it is now possible to design, formulate and employ new diacetylenic species and polymers formed therefrom to provide nonlinear optic, waveguide, piezoelectric, and pyroelectric materials and devices having surprising efficiencies and degrees of effect. According to a preferred embodiment of the invention, diacetylenes which are crystallizable into crystals having a non-centrosymmetric unit cell may form single crystals or may be elaborated into a thin film upon a substrate by the Langmuir-Blodgett technique. Such films may, optionally, be polymerized either thermally or by irradiation for use in nonlinear optical and other systems. According to other preferred embodiments, diacetylenes are covalently bonded to substrates through the employment of silane species and subsequently polymerized to yield nonlinear optic and other devices having high structural integrity in addition to high efficiencies and effects.

  本发明提供了新的非线性光学、压电、热释电、波导和其他材料，以及用于它们的工艺和形成的物品。这些材料、工艺和物品包括由二乙炔基物种形成的二乙炔烯和聚合物，这些聚合物易于进行几何、立体、结构和电子控制。因此，现在可以设计、制定和使用新的二乙炔基物种和形成的聚合物，以提供具有惊人效率和效果的非线性光学、波导、压电和热释电材料和器件。根据本发明的优选实施例，可以将可结晶成非中心对称晶胞晶体的二乙炔烯形成单晶体，或通过Langmuir-Blodgett技术在衬底上制成薄膜。这样的薄膜可以选择性地通过热或辐照聚合用于非线性光学和其他系统。根据其他优选实施例，通过使用硅烷物种使二乙炔烯共价键结到衬底上，随后聚合以产生高结构完整性以及高效率和效果的非线性光学和其他器件。
• Photographic articles comprising a compound having acetylenic bonds and methods for producing the articles
  申请人：UNIVERSITY PATENTS, INC.

  公开号：EP0077577A2

  公开（公告）日：1983-04-27

  This invention provide a novel photoresistive article having significantly improved properties of resultion when used as a photoresist. The article comprising a substrate and a layer carried by said substrate of a photopolymerizable composition which layer comprises at least one material having at least two acetylenic bonds, at least two of said bonds being in conjugation with one another and having a plurality of discrete domains. In one embodiment of the invention, within the discrete domain, a majority of the molecules of the material are oriented in an irregular array. The domains may have an average dimension of less than 10,000 angstom units and provides enhanced resolution of micro-structural lines in an image projected thereon.

  本发明提供了一种新型光致抗蚀剂制品，该制品在用作光致抗蚀剂时，其结果性能得到明显改善。 该制品包括基底和由所述基底承载的一层可光聚合的组合物，该层包括至少一种具有至少两个乙炔键的材料，其中至少两个键彼此共轭，并具有多个离散畴。 在本发明的一个实施例中，在离散畴内，材料的大部分分子以不规则阵列的方式定向。 这些畴的平均尺寸可小于 10,000 个角单位，并可提高投射到其上的图像中的微观结构线的分辨率。