(R)-2-[3-[(R)-1-(4-bromo-phenyl)-ethylcarbamoyl]-1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-1H-pyrazol-4-yloxy]-propionic acid | 1034264-27-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (R)-2-[3-[(R)-1-(4-bromo-phenyl)-ethylcarbamoyl]-1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-1H-pyrazol-4-yloxy]-propionic acid
• 英文别名: (2R)-2-[3-[[(1R)-1-(4-bromophenyl)ethyl]carbamoyl]-1-(2-chlorophenyl)-5-(4-chlorophenyl)pyrazol-4-yl]oxypropanoic acid
• CAS: 1034264-27-1
• 化学式: C₂₇H₂₂BrCl₂N₃O₄
• 分子量: 603.299
• InChiKey: WUEFBSYDIONFBU-HZPDHXFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  93.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• CB1 RECEPTOR MODULATORS
  申请人：Cooper Martin

  公开号：US20100010061A1

  公开（公告）日：2010-01-14

  Compounds of formula (I) suppress the normal signalling activity CB1 receptors, and are thus useful in the treatment of diseases or conditions which are mediated by CB1 receptor signalling activity, such as treatment of obesity and overweight, prevention of weigh gain, treatment of diseases and conditions directly or indirectly associated with obesity and overweight: wherein A 1 is hydrogen, —COOH, or tetrazolyl, and A 2 is hydrogen, —COOH, or tetrazolyl, provided that one of A 1 and A 2 is either —COOH or tetrazolyl; p is 0 or 1 and A 3 is phenyl or cycloalkyl, either of which is optionally substituted with R 4 and/or R 5 ; q is 0 or 1; R 3 is hydrogen, C 1 -C 4 alkyl, cycloalkyl, —CF 3 , or —OR 9 ; R 4 and R 5 independently —R 9 , —CN, —F, —Cl, —Br, —OR 9 , —NR 7 R 8 , —NR 7 COR 6 , —NR 7 SO 2 R 6 , —COR 6 , —SR 9 , —SOR 9 , or —SO 2 R 6 ; R 6 is C 1 -C 4 alkyl, cycloalkyl, —CF 3 or —NR 7 R 8 ; R 7 and R 8 are independently hydrogen, C 1 -C 4 alkyl, —CF 3 , or cycloalkyl; R 9 is hydrogen, C 1 -C 4 alkyl, cycloalkyl, fully or partially fluorinated C 1 -C 4 alkyl; R 1 is (i) a bond, or (ii) —(CH 2 ) a B 1 (CH 2 ) b — wherein a and b are independently 0, 1, 2 or 3 provided that a+b is 1, 2 or 3; or (iii) —C(R 10 )(R 11 )—*, —C(R 10 )(R 11 )—O—*, —C(R 10 )(R 11 )CH 2 —*, —C(R 10 )(R 11 )CH 2 —O—*, —CH 2 C(R 10 )(R 11 )—*, —CH 2 C(R 10 )(R 11 )—O—*, —CH 2 —O—C(R 10 )(R 11 )—* or —C(R 10 )(R 11 )—O—CH 2 —*, wherein the bond indicated by an asterisk is attached to the pyrazole ring; R 2 is a divalent radical of formula -Q 1 -A 4 -[Q 2 ] w - wherein Q1, A4 Q2 and w are as defined in the specification; and R 10 is hydrogen and R 11 is (C 1 -C 3 )alkyl or —OH; or R 10 and R 11 are both (C 1 -C 3 )alkyl; or R 10 and R 11 taken together with the carbon atom to which they are attached form a (C 3 -C 5 )cycloalkyl ring.

  式(I)的化合物抑制CB1受体的正常信号活动，因此在治疗由CB1受体信号活动介导的疾病或病症方面有用，例如治疗肥胖和超重，预防体重增加，直接或间接与肥胖和超重相关的疾病和病症的治疗：其中A1是氢，-COOH或四唑基，A2是氢，-COOH或四唑基，但A1和A2中的一个是-COOH或四唑基；p为0或1，A3是苯基或环烷基，其中任一种都可以被R4和/或R5取代；q为0或1；R3是氢，C1-C4烷基，环烷基，-CF3或-OR9；R4和R5独立地是-R9，-CN，-F，-Cl，-Br，-OR9，-NR7R8，-NR7COR6，-NR7SO2R6，-COR6，-SR9，-SOR9或-SO2R6；R6是C1-C4烷基，环烷基，- 或-NR7R8；R7和R8独立地是氢，C1-C4烷基，- 或环烷基；R9是氢，C1-C4烷基，环烷基，完全或部分氟化的C1-C4烷基；R1是（i）键，或（ii）-（CH2）aB1（ ）b-，其中a和b独立地为0、1、2或3，但a+b为1、2或3；或（iii）-C（R10）（R11）- *，-C（R10）（R11）-O- *，-C（R10）（R11） - *，-C（R10）（R11） -O- *，- C（R10）（R11）- *，- C（R10）（R11）-O- *，- -O-C（R10）（R11）- *或-C（R10）（R11）-O- - *，其中星号表示连接到吡唑环的键；R2是式-Q1-A4-[Q2]w-的二价基团，其中Q1，A4，Q2和w在规范中定义；R10是氢，R11是（C1-C3）烷基或-OH；或R10和R11都是（C1-C3）烷基；或R10和R11与它们所连接的碳原子一起形成（C3-C5）环烷基环。
• Improved ApoE analogs and methods for their use
  申请人：Cosnosci, Inc.

  公开号：EP2382983A1

  公开（公告）日：2011-11-02

  Novel ApoE peptides derivatives and ApoE-protein transduction domain conjugates are disclosed which are useful for treating disorders including CNS inflammation, traumatic brain injury, inflammatory bowel disease (also know as Crohn's Disease or ulcerative colitis), cerebral ischemia, atherosclerosis, sepsis, multiple sclerosis and arthritic diseases, Alzheimer's Disease and other brain disorders. The invention encompasses methods for protecting subjects having undergone irradiation or radiotherapy by administration of ApoE or at least one ApoE mimetic peptide.

  本发明公开了新型载脂蛋白E肽衍生物和载脂蛋白E-蛋白转导结构域共轭物，可用于治疗包括中枢神经系统炎症、创伤性脑损伤、炎症性肠病（又称克罗恩病或溃疡性结肠炎）、脑缺血、动脉粥样硬化、败血症、多发性硬化和关节炎、阿尔茨海默病和其他脑部疾病在内的疾病。本发明包括通过服用载脂蛋白或至少一种载脂蛋白模拟肽来保护接受过辐照或放疗的受试者的方法。
• US7947645B2
  申请人：——

  公开号：US7947645B2

  公开（公告）日：2011-05-24
• US8124598B2
  申请人：——

  公开号：US8124598B2

  公开（公告）日：2012-02-28
• US8124634B2
  申请人：——

  公开号：US8124634B2

  公开（公告）日：2012-02-28