(Z)-acetyloxymethoxyimino-[methyl-[2-[2-[4-[2-(4-sulfamoylphenyl)-5-(trifluoromethyl)pyrazol-3-yl]phenyl]acetyl]oxyethyl]amino]-oxidoazanium | 1186423-59-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (Z)-acetyloxymethoxyimino-[methyl-[2-[2-[4-[2-(4-sulfamoylphenyl)-5-(trifluoromethyl)pyrazol-3-yl]phenyl]acetyl]oxyethyl]amino]-oxidoazanium
• CAS: 1186423-59-5
• 化学式: C₂₄H₂₅F₃N₆O₈S
• 分子量: 614.559
• InChiKey: KSHUHZPSDIAWAJ-MEIHLTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  42
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  193
• 氢给体数：
  1
• 氢受体数：
  15

文献信息

• [EN] NO-RELEASING NONOATE(OXYGEN-BOUND)CHROMENE CONJUGATES<br/>[FR] CONJUGUÉS DE NONOATE(LIÉ À L'OXYGÈNE)CHROMÈNE LIBÉRANT DE L'OXYDE NITRIQUE
  申请人：EUCLISES PHARMACEUTICALS INC

  公开号：WO2015109014A1

  公开（公告）日：2015-07-23

  The present invention provides NO-releasing NONOate(oxygen bound)chromene conjugates, having the structure of Formula (I): wherein Z, R1, R2, R3, R4, R5, R6, and R7 are as defined in the detailed description; pharmaceutical compositions comprising at least one compound of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis, or acne, using a compound of Formula (I).

  本发明提供了释放NO的NONOate（氧结合）香豆素共轭物，其具有如下结构（I）的结构：其中Z、R1、R2、R3、R4、R5、R6和R7如详细描述中所定义；包括至少一种化合物的制药组合物（I）；以及使用化合物（I）有益于愈合伤口、预防和治疗癌症，或治疗光老化性角化症、囊性纤维化或痤疮的方法。
• [EN] NO-RELEASING NONOATE (NITROGEN-BOUND) SULFONAMIDE-LINKED-COXIB ANTI-CANCER AGENTS<br/>[FR] AGENTS ANTICANCÉREUX DE COXIB LIÉS À UN SULFONAMIDE (LIAISON À L'AZOTE) DE NONOATE À LIBÉRATION DE NO
  申请人：EUCLISES PHARMACEUTICALS INC

  公开号：WO2014012074A2

  公开（公告）日：2014-01-16

  The present invention provides NO-releasing NONOate(nitrogen bound)sulfonamide- linked-coxib anti-cancer agents, having the structure of Formula (I): wherein R1, X, L, R2, R3, R4, and Z are as defined in the detailed description; pharmaceutical compositions comprising at least one compound of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis or acne, using a compound of Formula (I).
• [EN] DEUTERATED NO-RELEASING NONOATE(OXYGEN-BOUND)CHROMENE CONJUGATES<br/>[FR] CONJUGUÉS DE CHROMÈNE DÉUTÉRÉ NONOATE(OXYGÈNE-LIÉ) LIBÉRANT DU NO
  申请人：EUCLISES PHARMACEUTICALS INC

  公开号：WO2015109017A2

  公开（公告）日：2015-07-23

  The present invention provides deuterated NO-releasing NONOate(oxygen bound)chromene conjugates, having the structure of Formula (I): wherein Z, R1, R2, R3, R4, R5, R6, and R7 are as defined in the detailed description; pharmaceutical compositions comprising at least one compound of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis, or acne, using a compound of Formula (I).