(RS)-3-[4-(tetrahydro-pyran-2-yloxymethyl)-oxazol-2-yl]-benzoic acid methyl ester | 473547-98-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (RS)-3-[4-(tetrahydro-pyran-2-yloxymethyl)-oxazol-2-yl]-benzoic acid methyl ester
• 英文别名: Methyl 3-[4-(oxan-2-yloxymethyl)-1,3-oxazol-2-yl]benzoate
• CAS: 473547-98-7
• 化学式: C₁₇H₁₉NO₅
• 分子量: 317.342
• InChiKey: TZFTWLWSTINBGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  70.8
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Dihydro-benzo [b] [1,4] diazepin-2-one derivatives
  申请人：——

  公开号：US20020193367A1

  公开（公告）日：2002-12-19

  This invention is a dihydro-benzo[b][1,4]diazepin-2-one derivative of the formula 1 wherein R 1 , R 2 , R 3 , X and Y are as defined in the specification. The invention includes pharmaceutical compositions containing these compounds, a process for their preparation, their use in preparation of pharmaceutical compositions and administration of an effective amount of the compounds for the treatment or prevention of acute and/or chronic neurological disorders to a patient in need of such treatment.

  这项发明涉及一种公式1中R1、R2、R3、X和Y如规范中所定义的二氢苯并[b][1,4]二氮杂环-2-酮衍生物。该发明包括含有这些化合物的药物组合物、制备它们的方法、它们在制备药物组合物时的使用以及给需要这种治疗的患者施用足够剂量的这些化合物以治疗或预防急性和/或慢性神经系统疾病。
• DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1379511A1

  公开（公告）日：2004-01-14
• US6544985B2
  申请人：——

  公开号：US6544985B2

  公开（公告）日：2003-04-08
• [EN] DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II<br/>[FR] DERIVES DIHYDRO-BENZO[B][1,4]DIAZEPIN-2-ONE UTILISES COMME ANTAGONISTES DE MGLUR2(II)
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002083652A1

  公开（公告）日：2002-10-24

  This invention is concerned with dihydro-benzo [b] [1, 4] diazepin-2-one derivatives of the general formula wherein R1, R2, R3 , X and Y are as defined in the specification. The invention further relates to medicaments containing these compounds, a process for their preparation as well as their use for preparation of medicaments for the treatment or prevention of acute and/or chronic neurological disorders.