6-((3-(4-(1,3-thiazol-4-ylcarbonyl)piperazin-1-yl)azetidin-1-yl)carbonyl)-2-(3-trifluoromethylphenyl)-1,3-benzoxazole | 1252765-80-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-((3-(4-(1,3-thiazol-4-ylcarbonyl)piperazin-1-yl)azetidin-1-yl)carbonyl)-2-(3-trifluoromethylphenyl)-1,3-benzoxazole
• 英文别名: [3-[4-(1,3-Thiazole-4-carbonyl)piperazin-1-yl]azetidin-1-yl]-[2-[3-(trifluoromethyl)phenyl]-1,3-benzoxazol-6-yl]methanone
• CAS: 1252765-80-2
• 化学式: C₂₆H₂₂F₃N₅O₃S
• 分子量: 541.554
• InChiKey: OUHODRJXTLINBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  111
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• [EN] AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS<br/>[FR] AZÉTIDINYL DIAMIDES EN TANT QU'INHIBITEURS DE LA MONOACYLGLYCÉROL LIPASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2010124082A1

  公开（公告）日：2010-10-28

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I), wherein Y, Z, R1, and s are defined herein.

  公开了用于治疗各种疾病、综合症、状况和障碍，包括疼痛的化合物、组合物和方法。这些化合物由式（I）表示，其中Y、Z、R1和s在此定义。
• AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
  申请人：Janssen Pharmaceutica N.V.

  公开号：EP2421823B1

  公开（公告）日：2015-01-14
• US8362000B2
  申请人：——

  公开号：US8362000B2

  公开（公告）日：2013-01-29
• [EN] AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS<br/>[FR] DIAMIDES D'AZÉTIDINYLE UTILISÉES COMME INHIBITEUR DE LA MONOACYLGLYCÉROL LIPASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2010124114A1

  公开（公告）日：2010-10-28

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) wherein Y, Z, R1, and s are defined herein.
• [EN] AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS<br/>[FR] DIAMIDES D'AZÉTIDINYLE INHIBITRICES DE LA MONOACYLGLYCÉROL LIPASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2010124116A1

  公开（公告）日：2010-10-28

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: Formula (I) wherein Y, Z, R1, and s are defined herein.